慢加亚急性肝衰竭患者血清内毒素、胃泌素、胃动素的关系及临床意义

Association between endotoxin,gastrin and motolin in subacute-on-chronic liver failure patients and the clinical value

目的探讨慢加亚急性肝衰竭患者内毒素、胃泌素、胃动素水平及其相关性。方法检测69例慢加亚急性肝衰竭患者(早期26例,中期21例,晚期22例,并发上消化道出血12例)各期内毒素、胃泌素、胃动素水平,并分析其相关性。结果①血清内毒素、胃泌素、胃动素与肝损伤程度有关,合并上消化道出血时以上各指标水平最高;各组之间两两比较,差异有统计学意义(P均<0.01)。②慢加亚急性肝衰竭患者血清内毒素与胃泌素及胃动素水平呈显著相关(r=0.93,0.98;P均<0.01)。结论慢加亚急性肝衰竭患者内毒素、胃泌素、胃动素水平,与肝损伤程度相关,是上消化道出血的重要因素。

Objective To investigate the relationship between the endotoxin（ET） ,gastrin （Gas）and motolin（MTL） of subacute-on-chronic liver failure（SACLF） patients and their dependability. Methods 69 SACLF inpatients came from our department, and of them, there were 26 cases in early period, 21 cases in middle period and 22 cases in terminal peried, of which 12 cases went with upper gastrointestinal hemorrhage complication. The levels of ET, Gas, MTL were detected , and their relationship were analyzed. Rusults （1）ET, Gas and MTL were positively related to the degree of live injury. Compared to other three groups, the mean of the group with upper gastrointestinal hemorrhage complication was largest. There were significant difference between every two groups （ P 〈 0. 01 ）. （2）ET was significantly corelated with Gas and MTL in SACLF inpatients（r = 0.93, 0.98 ; P 〈 0.01 ）. Conclusions The levels of ET, Gas and MTL are high in the SACLF patients and related to the liver injury degree positively. They are important factors for upper gastrointestinal hemorrhage.