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神经肽Y对多发性硬化影响的实验研究

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摘要 将20只豚鼠随机分为实验性变态反应性脑脊髓炎(EAE)对照组、神经肽Y(NPY)干预组。观察两组豚鼠发病潜伏期、神经功能障碍评分、死亡率及病理改变。发现NPY干预组发病后潜伏期明显比EAE对照组延长,发病高峰期神经功能障碍评分明显降低,死亡率降低,且病理改变程度较轻。提示NPY对多发性硬化的动物模型EAE在发病症状和病理上都能起到保护作用。
出处 《山东医药》 CAS 北大核心 2009年第20期41-42,共2页 Shandong Medical Journal
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参考文献8

  • 1Render MP,Sears TA.The pathophysiology of acute experimental allergic encephalomyelitis in the rabbit[J].Brain,1984,107(Pt 3):699-726.
  • 2Noble EP,Wurtman RJ,Axelrod J.A simple and rapid method for injecting H3-norepinephrine into the lateral ventricle of the rat brain[J].Life Sci,1967,6(3):281-291.
  • 3董梅,刘瑞春,郭力,李春岩.Wistar大鼠实验性变态反应性脑脊髓炎的模型建立[J].脑与神经疾病杂志,2004,12(6):425-428. 被引量:19
  • 4Raine CS,Barnett LB,Brown A,et al.Neuropathology of experimental allergic encephalomyelitis in inbred strains of mice[J].Lab Invest,1980,43(2):150-157.
  • 5Crowe MJ,Bresnahan JC,Shuman SL,et al.Apoptosis and delayed degeneration after spinal cord injury in rats and monkeys[J].Nat Med,1997,3(1):73-76.
  • 6Chronwall BM,Dimaggio DA,Massari VJ,et al.The anatomy of neuropeptide Y containing neurons in rat brain[J].Neuroscience,1985,15(4):1159-1181.
  • 7O' Donohue TL,Chronwall BM,Pruss RM,et al.Neuropeptide Y and peptide YY neuronal and endocrine systems[J].Peptides,1985,6(4):755-768.
  • 8童永光,薛永涛,张旭,鞠躬.神经肽Y-Y_1受体样免疫反应物质在大鼠中枢神经系统的分布[J].解剖学报,1998,29(2):124-129. 被引量:3

二级参考文献15

  • 1Nikki CO, Brien C, Brett C et al. Inhibition of nitric oxide synthase initiates relapsing remitting experimental autoimmune encephalomyelitis in rats, yet nitric oxide appears to be essential for clinical expression of disease. J Immunol, 2001,167(10):590
  • 2Legge KL, Min B, Bell JJ, et al. Coupling of peripheral tolerance to endogenous interleukin 10 promotes effective modulation of myelin-activated T cells and ameliorates experimental allergic encephalomyelitis. J Exp Med. 2000;191(12):2039
  • 3Giok K, Kuniko K, Naoyuki T, et al. Persistent expression of experimental autoimmune encephalomyelitis (EAE)-specific Vβ8.2 TCR spectrarype in the central nervous system of rats with chronic relapsing EAE. J Immunol, 1998,161(12):6993
  • 4Maatta JA, Eralinna JP, Roytta M, et al. Physical state of the neuroantigen in adjuvant emulsions determines encephalitogenic status in the BALB/c mouse. J Immunol Method. 1996,190:133
  • 5Fulumitsu H, Talase YS, Watanabe R. Neuropathology of autoimmune encephalomyelitis modified by retroviral infection. Neurophathology, 2002,22(4):280
  • 6Bert A, Sandra A. The use of animal models to investigate the pathogenesis of neuroinflammatory disorders of the central nervous system. Curr Opin Neurol. 2003;16(3):375
  • 7张旭,Proc Natl Acad Sci USA,1994年,91卷,24期,11738页
  • 8Sambrook J,分子克隆实验指南(第2版),1992年,888页
  • 9Shu S Y,Neurosci Lett,1988年,85卷,2期,169页
  • 10胡学强,陆正齐,饶从志,吴金浪,吴义芳.实验性变应性猴脑脊髓炎的超微结构改变[J].中华神经科杂志,1998,31(6):333-335. 被引量:9

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