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BRCA 1与乳腺癌研究的进展 被引量：4

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摘要 BRCA1是第一个被鉴别出来的人类乳腺癌易感基因,是乳腺癌及卵巢癌特异性抑癌基因。笔者结合文献就其结构和功能、BRCA1与miRNA的联系、BRCA1与乳腺干细胞及乳腺癌干细胞的关系作一综述。
作者 林帅 吴诚义
机构地区 重庆医科大学附属第一医院内分泌外科
出处 《中国普通外科杂志》 CAS CSCD 北大核心 2009年第5期501-504,共4页 China Journal of General Surgery
关键词 乳腺肿瘤 BRCA1 MIRNA 乳腺干细胞 乳腺癌干细胞 Basal-like乳腺癌
分类号 R737.9 [医药卫生—肿瘤]
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参考文献26

  • 1Miki Y, Swensen J, Shattuck- Eidens D, et al. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1 [ J ]. Science, 1994,266(5182) :66 -71.
  • 2King MC, Marks JH, Mandell JB. Breast and ovarian cancer risks due to inherited mutations in BRCA 1 and BRCA2[J]. Science, 2003,302 (5645) :643 -646.
  • 3Janatova M, Zikan M, Dundr P, et al. Novel somatic mutations in the BRCA1 gene in sporadic breast tumors[J]. Hum Mutat,2005,25 (3) :319.
  • 4Narod SA, Foulkes WD. BRCA1 and BRCA2: 1994 and beyond [J]. Nat Rev Cancer, 2004,4 (9) :665 -676.
  • 5Calin GA, Dumitru CD, Shimizu M, et al. Frequent deletions and down-regulation of micro- RNA genesmiR15 and miR16 at 13q14 in chronic lymphocytic leukemia [ J ]. Proc Natl Acad Sci USA ,2002, 99 (24) :15524- 15529.
  • 6Chan JA, Krichevsky AM, Kosik KS. MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells [ J ]. Cancer Res, 2005, 65 (14) :6029-6033.
  • 7Iorio MV, Ferracin M, Liu CG, et al. MicroRNA gene expression deregulation in human breast cancer [ J ]. Cancer Res, 2005, 65 ( 16 ) : 7065 -7070.
  • 8Cimmino A, Calin GA, Fabbri M, et al. miR- 15 and miR- 16 induce apoptosis by targeting BCL2 [ J ] . Proc Natl Acad Sci USA, 2005, 102(39) :13944-13949.
  • 9Johnson SM, Grosshans H, Shingara J, et al. RAS is regulated by the let-7 microRNA family [ J ] . Cell, 2005,120(5) :635 -647.
  • 10Negrini M, Calin GA. Breast cancer metastasis : a microRNA story [ J ]. Breast Cancer Res, 2008, 10 (2) :203.

同被引文献81

  • 1Perou CM, Sorlie T, Eisen MB, et al. Molecular portraits of human breast tumours [ J ]. Nature, 2000, 406 ( 6797 ) : 747 - 752.
  • 2Sodie T, Perou CM, Tibshirani R, etal. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications [ J ]. Proc Natl Acad Sci USA, 2001, 98 ( 19 ) : 10869 -10874.
  • 3Sorlie T, Tibshirani R, Parker J, et al. Repeated observation of breast tumor subtypes in independent gene expressio, data sets [ J ]. Proc Natl acad Sei USA,, 2003, 100 (14) : 8418 -8423.
  • 4Carey LA, Dees EC, Sawyer L, et al. The triple negative paradox : primary tumor chemosensitivity of breast cancer subtypes [ J ]. Clin CancerRes, 2007, 13 (8) : 2329 - 2334.
  • 5Livasy CA, Karaca G, Nanda R, et al. Phenotypic evaluation of the basal-like subtype of invasive breast carcinoma [ J ]. Mad Pathol, 2006, 19(2) : 264 -271.
  • 6Nielsen TO, Hsu FD, Jensen K, et al. Immunohistochcmical and clinical characterization of the basal-like subtype of invasive breast carcinoma [J]. Clin Cancer Res, 2004, 10 (16): 5367-5374.
  • 7Badve S, Turbin D, Thorat MA, et al. FOXA1 expression in breast cancer correlation with luminal subtype A and survival [ J ]. Clin Cancer Res, 2007, 13 ( 15 ) : 4415 -4421.
  • 8Staid M,Wang Y,Zhang Y,et al. Subtypes of breast cancer show pref- erential site of relapse [ J ]. Cancer Res, 2008, 68 (9) : 3108 - 3114.
  • 9Sorlie T. Molecular portrait s of breast cancer: tumour subtypes as distinct disease entities [ J ]. Eur J Cancer, 2004, 40(18) : 2667 -2675.
  • 10Rodruquez - Pinilla SM, Sarrio D, Hon- rado E, et al. Vimentin and laminin expression is associated with basal- like phcnotype in both sporadic and BRCA 1 -associated breast carcinomas [ J]. J Clin Pathol, 2007, 60 (9) : 1006 - 1012.

引证文献4

二级引证文献14

中国普通外科杂志
2009年 第5期

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