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PSCA和Oct-4蛋白在肝细胞癌中的表达及其意义

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摘要 目的探讨PSCA和Oct-4蛋白在肝细胞癌(HCC)中的表达及其意义。方法利用免疫组织化学技术检测PSCA和Oct-4蛋白在肝硬化、肝细胞癌及其癌旁肝组织中的表达。结果结果PSCA和Oct-4蛋白阳性信号主要位于细胞质和细胞膜;HCC组织中PSCA和Oct-4蛋白的阳性率和阳性表达强度明显高于癌旁肝组织和肝硬化组织(P<0.01);HCC中PSCA和Oct-4蛋白的阳性表达率和表达强度与其组织学分级无关。在肝硬化及癌旁肝组织中,非典型增生的肝细胞PSCA和Oct-4蛋白呈强表达,且其表达率和表达强度与HCC的差异无统计学意义(P>0.05)。在肝硬化、HCC及其癌旁肝组织中,2种蛋白的表达强度呈显著正相关。结论肝硬化及癌旁肝组织中高表达PSCA和Oct-4蛋白的细胞可能是"癌干细胞",它们主要参与HCC的发生,且两者可能具有协同作用,检测肝硬化组织中PSCA和/或Oct-4蛋白的表达水平可能有助于早期发现HCC。
作者 刘水平 郭慧
机构地区 中南大学生物科学与技术学院分子生物研究中心 湖南省肿瘤医院病理科
出处 《中国普通外科杂志》 CAS CSCD 北大核心 2009年第5期530-532,共3页 China Journal of General Surgery
关键词 癌 肝细胞 肝硬化 前列腺干细胞抗原 OCT-4
分类号 R735.7 [医药卫生—肿瘤]
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参考文献11

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中国普通外科杂志
2009年 第5期

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