儿童过敏性紫癜血清D-二聚体检测的临床意义

Clinical significances of D-dimer in plasma of children with Henoch-Schonlein's purprua

目的通过检测健康对照组与过敏性紫癜患儿体内D-二聚体,以及过敏性紫癜肾型和非肾型D-二聚体,以探讨其临床意义。方法观察健康对照组40例,过敏性紫癜患儿37例,测定D-二聚体的量,将H SP患儿和健康对照组D-二聚体水平作比较。结果健康对照组与过敏性紫癜患儿体内D-二聚体,以及过敏性紫癜肾型和非肾型D-二聚体阳性率比较差异有统计学意义(P<0.01)。结论过敏性紫癜患儿存在血液高凝状态,血小板功能增强及微血栓形成,过敏性紫癜肾型D-二聚体阳性率明显高于其他型过敏性紫癜患儿,说明D-二聚体阳性患儿,发生肾脏损害危险性高于D-二聚体阴性患儿,常提示预后不良。

Objective To probe into the cilinical significances of D-Dimer on the healthy children and the children with Henoch-Schonlein＇s purprua（HSP）, including the children with Henoch-Schonlein＇s purprua nephritis （HSPN）and the children with non- Henoch-Schonlein＇s purprua nephritis （NHSPN）.Methods The plasma D-Dimer levels of 37 children,including 40 healthy children as control group,and 37 children with HSP,were determined and contrasted. Results There was significant difference between the positive ratio of the children with HSP and the control group. There was significant difference between the positive ratio of the children with HSP and the children with NHSP.Conclusion The blood solidified easily,the function of platelet improved and the minor thrombus formed easily in the children with HSP. The positive ratio of D-dimer in children with HSP nephritis was higher than that of children with NHSPN.The children with positive D-dimer have high risk of injuring kidney than the children with negative D-dimer and bad ending.