无精症患者睾丸病理、性激素水平及睾丸容积检测

Testicular biopsy and determination of sexual hormone and testicular volume in patients with azoospermia

目的:观察无精症患者睾丸病理、血清性激素水平及睾丸容积变化。方法:对97例无精症患者[A组32例(唯支持细胞综合征),B组28例(精子发育停滞于精母细胞)、C组37例(生精功能低下)]与正常对照40例(D组)进行睾丸活检病理、性激素和睾丸容积检测。结果:A、B、C组FSH和Johnsen评分均有差异(P<0.05)。A、B组睾丸容积低于C、D组,而LH水平高于C、D组(P<0.05),B组E2水平低于其他各组(P<0.05)。结论:FSH结合睾丸活检病理与睾丸容积可作为判断睾丸生精功能的重要指标。

Aim ： To observe the testicular pathology and changes in serum levels of the reproductive hormones and testieular volume in patients with azoospermia. Methods：A total of 97 patients with azoospermia were allocated into group A： 32 eases of sertoli cell only symdrome, groups B ： 28 cases of germinal arrest in the spermatocyte, groups C： 37 eases of hypospermatogenesis. Tcsticular biopsy, the reproductive hormones and the testicular volume were examined, and 40 normal individuals were chosen as control group. Results：FSH and Johnsen score of group A, B and C had significant differences （ P 〈 0.05）. The testicular volumes of group A and B were significantly lower than those of group C and D, while the levels of LH in group A and B were significantly higher than those of group C and D （ P 〈 0. 05 ）. The levels of E2 in group B was lower than the other groups （P 〈 0. 05 ）. Oonclusion ： FSH with testicular biopsy and testicular volumes could be used as the key indicators of spermatogenic function.