鼻息肉组织中肝细胞生长因子及血管内皮生长因子的表达

Expression of hepatocyte growth factor and vascular endothelial growth factor in nasal polyps

目的:检测鼻息肉组织中肝细胞生长因子(HGF)及血管内皮生长因子(VEGF)的表达。方法:采用免疫组织化学方法分别检测30例鼻息肉标本和20例正常下鼻甲黏膜标本中HGF与VEGF的表达。结果:鼻息肉组织中可见大量嗜酸性粒细胞浸润。鼻息肉组织中HGF和VEGF蛋白的阳性表达率分别为83.3%和76.7%,均高于正常对照组(30.0%和10.0%,P<0.05),且在鼻息肉血管内皮细胞及间质浸润的炎症细胞中2者的表达呈正相关(r=0.630,P<0.05;r=0.514,P<0.05)。结论:鼻息肉组织中HGF和VEGF的表达增强,提示2者可能协同参与鼻息肉的形成。

Aim ： To evaluate the relationship between the expression of hepatocyte growth factor（HGF） and vascular endothelial growth factor（VEGF） in nasal polyp（NP） tissue. Methods： HE staining and immunohistochemical assay were carried out in 30 cases of NP tissue and normal inferior turbinate （IT） tissue to detect the expression of VEGF and HGF. Results：It was found that there was the infiltration of eosinophils in NP tissue. The positive expression rates of HGF and VEGF in NP tissue were 83.3% and 76.7% ,higher than those in normal IT tissue （30.0% and 10.0% , P 〈 O. 05 ） . The 2 parameters were positively correlated in vascular endothelial and the infiltrating inflammatory cells in the matrix of NP（ r = 0. 630, P 〈 0.05 ; r = 0.514, P 〈 0.05 ）. Conclusion ： HGF and VEGF are strongly expressed in NP tissue. Their coordina- ting effects might play a role in the pathological development of NP.