LyGDI在肺癌组织中的表达及临床意义

Expression of LyGDI in Human Lung Cancer and Its Clinical Significance

目的研究LyGDI在肺癌组织中的表达及临床意义。方法用免疫蛋白印迹法分析肺癌及癌旁正常组织中LyGDI蛋白的表达情况。结果37份配对组织标本中,LyGDI在29份肺癌组织中的表达明显高于其相应的癌旁正常组织,差异有统计学意义(P<0.05)。肺癌组织中的小细胞癌(SCLC)与非小细胞癌(NSCLC)LyGDI表达的差异无统计学意义(P>0.05)。在NSCLC中,LyGDI的表达与分化程度(P<0.01)、淋巴结转移(P<0.05)有关,与性别(P>0.05)、年龄(P>0.05)、组织学分类(P>0.05)、分期(P>0.05)无关。结论肺癌组织中LyGDI蛋白的表达与组织分化程度及淋巴结转移存在相关性,与临床病理类型无相关性。LyGDI可能与肺癌的发生、发展有关。

Objective To investigate role of LyGDI protein in human lung cancer and to evaluate its clinical significance. Methods The differential protein expression of LyGDI between lung cancer and its corresponding normal lung tissue was analyzed by Western blot hybridization using well characterized monclonal antibodies. Results Results of Western blot suggested that the expression of LyGDI polycloral was significantly high in lung cancer compared with the corresponding normal lung tissue in 29 case （P〈0.05）. It was not associated with SCLC tsmall cell lung cancer） and NSCLC （non-small cell lung cancer） differentiation of lung cancer. In NSCLC, the expression of LyGDI was associated with lymph node metasis（P〈0.05）and histology（P〈0.01）, but it did not seem to vary among gender（P〉0.05）,age （P〉0.05）,pathology（P〉0.05）and stage（P〉0.05）. Conclusion The expression of LyGDI is associated with the metasis and histological of lung cancer. There was poor clinical and pathological difference for LyGDI LyGDI may play a role in lung cancer.