感染高危因素、分娩方式、胎龄对新生儿免疫功能的影响

The effects of perinatal infection,mode of delivery,gestational age on the immune function of newborn

目的探讨围产期感染高危因素、分娩方式、胎龄等多种因素对新生儿免疫功能的影响。方法选取产科单胎分娩产妇304例,采用免疫比浊法测定新生儿脐血IgA、IgG、IgM及补体C3、C4。结果(1)感染高危组IgA、IgM含量明显高于对照组(P<0.01);(2)阴道分娩组IgG含量明显高于剖宫产组(P<0.05);(3)早产组IgG、补体C3、C4含量明显低于非早产组(P<0.01)。结论母体存在感染高危因素对新生儿免疫功能有一定的影响;阴道分娩可促进新生儿免疫功能的增强;早产儿免疫功能不成熟。

Objective To discuss the effects of perinatal infection, mode of delivery, gestational age and other factors on the immune function of newborn. Methods Levels of neonatal cord blood IgA, IgG, IgM and complement C3 , C4 was determined by immunohistochemistry in 304 cases single birth mothers in our hospital obstetrics. Results W1. Levels of IgA, IgM in high risk infected group were significantly higher than those in the studyed group （P 〈 0.01 ） ;2. The level of IgG content in vaginal delivery group was significantly higher than that in the cesarean section group （P 〈 0.01 ） ;3 The preterm group of IgG, complement C3, C4 were significantly lower than those in the non - preterm group（P 〈 0.01 ）. Conclusions The existence of the high risk infected maternal factors has a certain impact on immune function; Vaginal delivery can promote immune function in newborn ; the immune function of premature infants is not mature.