植物生物反应器研究现状、瓶颈及策略

Research Progress,Bottlenecks and Strategies in the Plant Bioreactor

近10年,植物作为重组蛋白生产系统是生命科学中研究最活跃领域之一。植物系统具有低成本、安全和易规模化优势,其表达生物活性药用蛋白能力已被许多研究所证实;同时,植物药用蛋白产品还表现出潜在的市场和广阔应用前景。鉴于此,回顾了植物生物反应器兴起,介绍了植物表达系统和重组蛋白研究现状,综述了植物生物反应器面临瓶颈问题、解决对策和未来一段时间内研究热点;在展望植物生物反应器前景同时,对我国研究现状、与国外差距和未来发展应采取策略进行了讨论。

Past decade, plants as production systems for recombinant proteins has been actively investigated, and is one of the most active research fields in life sciences. Plants are attractive as protein factories because they with advantages of cost, scale, and safety, and emerge capability to produce pharmaceutical production with bioactivity proved by previously studies. The plant-made pharmaceuticals possess enormous viability for market and wide prospects for application. Based on those reasons, the rise of plant bioreactor was reviewed, and research advance on the expression systems and plant-made recombinant proteins was introduced. Bottleneck hotspot in Synchronou problems and adopted strategies using plant system to produce recombinant proteins and research the near future were summarized, and prospect of plant bioreactor in future was described. sly, some opinions including research progress of plant bioreactor, differences to foreign and strategies in the future were discussed.