摘要
阿奇霉素是在红霉素结构上修饰后得到的一种新大环内酯类广谱抗生素,其抗菌谱广,抗菌活性高,药代动力学性能好,有着极其重要的应用和发展前景,已被列入未来10年的畅销药物之一.综述了国内外阿奇霉素的合成路线与工艺流程、国内外阿奇霉素合成工艺研究现状,讨论分析了各合成步骤的技术关键,展望了阿奇霉素合成研究的趋势.
Azithromycin is a new broad-spectrum macrolide antibiotics that is modified in the structure of erythromycin. It is a broad-spectrum antibbiotic with strong antibacterial activity and more favorable pharmacokinetic behavior. And it shows a bright future in the application and development. It has been included one of the best-selling drug in the next ten years. It was reviewed about the synthesis process line of azithromycin and azithromycin Synthesis research at home and abroad. It was discussed the key technology of various steps and prospected of the trends of Azithromycin synthesis.
出处
《天中学刊》
2009年第2期11-15,共5页
Journal of Tianzhong
基金
河南省科技发展计划重点科技攻关项目(092102310208)
驻马店市科技发展计划科技攻关资助项目(073008)
关键词
阿奇霉素
红霉素肟
合成
贝克曼重排
甲基化
azthromycin
oximation of erythromycin
synthesis
beckmann rearrangement
methylation
