酒石酸布托啡诺用于全麻术后镇痛的临床观察

Clinic Observation of Butorphanol's Analgetic Effect on General Anaesthesia

目的：评价布托啡诺用于全麻手术后进入麻醉复苏室的病人的可行性和安全性。方法：选择90例全麻病人随机分为布托啡诺组（A组=30）、杜冷丁组（B组=30）和不给予任何镇痛药物组（C组=30），A组给予酒石酸布托啡诺1～2mg静脉莫非氏滴管静注；B组给予杜冷丁50-100mg肌注。观察并记录A、B两组注药后10min、30min、1h、4h的疼痛视觉模拟评分（VAS值）、镇静评分（采用Ramsay评分）、生命体征的变化和不良反应的发生情况并与C组进行对照分析。结果：给予镇痛药的两组的镇痛镇静率均在86％以上，但是布托啡诺组的副反应如心慌、呼吸抑制较杜冷丁组少。布托啡诺组术后恶心、呕吐发生率低于不给药物组（P〈0．05），注药后1h布托啡诺组头晕和嗜睡的发生率明显高于杜冷丁组（P〈0．05）。结论：布托啡诺和杜冷丁用于麻醉复苏室患者均具有良好的术后镇痛效果，术后不良反应发生率低。

Objective： To evaluate the safety and feasibility of Butorphanol applied in post-operative patients with general anaesthesia. Methods： 90 cases of patients with general anaesthesia were selected and randomly divided into three groups. Group A were intravenously treated with Butorphanol, group B were intramuscularly treated with Pethidine, and group C as the control. These cases were observed and comparatively analyzed.Results： The rate of pain relief in both group A and B were over 86% .But there had less side effects in group A than those in group B, such as palpitation and breath suppress. And the rate of dizziness and somnolence was significantly higher in group A than those in group B. Conclusion： Butorphanol and Pethidine are safe and effective in resuscitation and have fewer side effects.