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醋酸甲羟孕酮原位凝胶植入剂的制备及体外药物释放评价

Preparation and Evaluation of In Situ Gel Implants Containing Medroxy Progesterone Acetate(MPA-PLA) In Vitro
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摘要 采用正交设计法对醋酸甲羟孕酮原位凝胶植入剂(MPA-PLA)进行处方筛选,优化制备工艺。以高效液相为检测方法,评价该制剂的体外释放规律。结果显示:MPA-PLA能显著延长释放时间,具有长效缓释制剂的基本释药规律。 The optimal prescription was selected to prepare MPA - PLA and the release of MPA - PLA in vitro was determined by a rapid and sensitive high - performance liquid chromatography （HPLC） assay . The results show that MPA- PLA has long- term sustained release.
作者 李婷婷 曾忠良 陈刚莲 胡启飞
机构地区 西南大学药学院 重庆康刻尔制药有限公司
出处 《中国兽药杂志》 2009年第5期2-4,共3页 Chinese Journal of Veterinary Drug
关键词 原位凝胶植入剂 正交设计 体外评价 长效缓释 in situ gel implants orthogonal design evaluation in vitro long- term sustained release
分类号 R914.2 [医药卫生—药物化学]
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中国兽药杂志
2009年 第5期

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