青年脑梗死患者早期应用他汀类药物对炎性介质的影响

Effects of statins on proinflammatory cytokine levels in young patients with cerebral infarction

目的观察青年脑梗死(年龄小于45岁)患者早期给予辛伐他汀后血中炎性介质的变化,探讨青年脑梗死早期应用他汀类药物的必要性。方法将发病时间小于72 h的青年脑梗死患者100例,随机分为两组,他汀组50例,对照组50例,采用双抗体夹心酶联免疫吸附法(ELISA)测定用药前后血中C反应蛋白(CRP)、肿瘤坏死因子(TNF)-a的含量及血脂变化。结果两组CRP、TNF-a两项指标均较入院时升高。他汀组CRP、TNF-a升高的幅度低于对照组,差异均有统计学意义(P均<0.05)。结论在青年脑梗死早期给予辛伐他汀治疗可以降低炎性因子升高的幅度,有利于动脉粥样硬化斑块的稳定及脑损伤的恢复。

Objective To observe the effects of simvastatines on plasma proinflammatory cytokine in patients with cerebral infarction （age〈45years）. Methods 100 patients with cerebral infarction were recruited. They were divided randomly into treatment group and control group. Patients in treatment proup were treated with simvastatine 20mg/d, lw, but patients in control group were not treated with lipanthyl tablets, other treatments were the same. Enzyme-linked immunoadsorbent assay（ELISA） method was used to determine TNF-α and CRP serum levels before and after treatment. Results Serum levels of TNF-α and CRP in patients received simvastatine therapy were significantly lower than those in patients without therapy （P〈0.05）. Conclusion Simvastatine can lower proinflammatory cytokine levels, and treat young patients with cerebral infartion effectively.