丁苯酞治疗急性脑梗死的疗效观察

Effect observation on butylphthalide treating acute cerebral infarction

目的评价国家Ⅰ类新药丁苯酞治疗急性脑梗死的疗效。方法将100例急性脑梗死患者随机分丁苯酞治疗组50例和对照组50例。对照组给予银杏叶提取物注射液20ml静滴,1次/d;阿司匹林100mg口服,1次/d,疗程2周;治疗组在对照组基础上给予丁苯酞软胶囊口服0.2g/次,3次/d,疗程2周。治疗结束时进行临床疗效观察并评定治疗前后神经功能缺损评分的变化。结果丁苯酞治疗组的治愈率、显效率及总有效率高于对照组(P<0.05),差异具有统计学意义。结论丁苯酞治疗急性脑梗死有显著疗效,且用药安全。

Objective To evaluate the effects of national new drug butylphthalide in the treatmant of acute cerebral infarction. Methods One hundred patients with acute cerebral infarction were divided into two groups randomly. Fifty patients in control group were treated with extract of Ginkgo Biloba leaves injection 20ml, iv gtt, qd, and Aspirin 100mg, po, qd, while treatment group was given butylphthalide 0.2g, po, rid, and individually the former basic treatment, with a course of 14d for each group. All selected patients were .undertaken evaluation of the clinical therapeutic effect and nervous functional deficiency degree before and after the treatment. Results After treatment,the heal rate,efficacy rate and total efficacy rate in treatment group all increased,there was a significant difference in the nervous functional deficiency degree between treatment group and control group （P〈0.05）. Conclusion Butylphthalide is effective and safe for acute cerebral infarction.