运动心肺功能试验在慢性阻塞性肺疾病临床评价中的作用

Cardiopulmonary Exercise Testing in Evaluation for Patients with Chronic Obstructive Pulmonary Diseases

目的探讨运动心肺功能试验(CPET)在慢性阻塞性肺疾病(COPD)临床评价中的作用及与静态肺功能之间的关系。方法对26例稳定期COPD患者、30例正常对照进行踏车下的负荷递增的运动心肺功能和静态肺功能检查。结果COPD组最大耗氧量(VO2max)、无氧阈(AT)、最大通气量(VEmax)、通气储备(BR)均低于正常对照组(P<0.05);最大做功(Wmax)、氧脉搏在两组间无显著性差异(P>0.05);COPD组VO2max、AT、VEmax、BR与第1秒用力呼气量(FEV1)及呼气峰值流量(PEF)呈正相关(P<0.05),与用力肺活量(FVC)及FEV1/FVC无相关(P>0.05)。结论运动心肺功能参数与静态肺功能参数呈相关关系,运动心肺功能测定可用于COPD患者早期的临床评价。

Objective To investigate the evaluation of cardiopulmonary exercise test （CPET） in the patients with chronic obstructive pulmonary disease （COPD）, and the relationship with the pulmonary function test （PFT）. Methods 26 COPD patients and 30 normal controls were examined with CPET and PFT. Results The parameters of CPET, including maximum oxygen uptake （VO2max）, anaerobic threshold （AT）, maximum minute ventilation （VEmax） and breathing reserve （BR） were lower in COPD group than those in control group （P〈0.05）. There were no significant differences in Wmax, oxygen pulse （O2 pulse） between two groups （P〉0.05）. VO2 max, AT, VEmax and BR were positively correlated with forced expiratory volume in one second （FEV1） and peak expiratory flow （PEF） in COPD group （P〈0.05）, but were not correlated with forced vital capacity （FVC） and FEV1/ FVC （P〉0.05）. Conclusion The pulmonary function of COPD patients can be evaluated with CPET, especially VO2max, AT, VE max and BR.