2型糖尿病患者血管性病变与血小板参数变化的观察

The relation between platelet indices and vascular lesion in patients with T_2DM

目的探讨血小板参数测定对糖尿病血管病变的诊断价值。方法86例2型糖尿病(T2DM)患者作为观察组(T2DM组),另选46例健康体检者作为对照组。2组均为清晨空腹采集静脉血5ml,分别检测血小板总数(PLT)、血小板平均体积(MPV)、血小板压积(PCT)、血小板分布宽度(PDW)及分离血清检测葡萄糖(Glu)。结果T2DM组空腹血糖(FPG)为(11.9±6.9)mmol/L,显著高于对照组的(4.5±1.7)mmol/L(P<0.01);有血管病变组较无血管病变组FPG比较差异无统计学意义(P>0.05)。T2DM组与健康对照组比较,MPV、PDW明显增大(P<0.01),PLT计数降低(P<0.05);而2组间PCT检测值无明显差异(P>0.05)。有血管病变组较无血管病变组MPV和PDW明显增高(P<0.01),PLT计数低于无血管病变组(P<0.05),2组间PCT检测值无明显差异(P>0.05)。结论血常规中血小板参数检查对发现T2DM有无血管病变有一定的临床意义。

Objective To investigate the clinical value of the platelet indices in the spectrum of thrombocytopenia. Methods 86 patients with vascular lesion were in observation group, and 46 healthy persons were choosed as the control group. The level of PLT, MPV, PCT, PDW and Glu were detected and compared. Results The FPG in observation was （ 11.9 ± 6.9） mmol/L , much higher than （4.5± 1.7 ） mmol/L in control group （ P 〈 0.01 ）, and there was obvious difference in MPV, PDW and PLT between the two groups（ P 〈 0.01 or P 〈 0.05 ） except PCT（ P 〉 0.05 ）. The level of FPG was not different between vascular lesion group and non - vascular lesion group（ P 〉 0.05 ）, but MPV, PDW and PLT were obviously different （ P 〈 0.01 or P 〈 0.05 ）. Conclusion The platelet indices could provide important clinical information about the underlying conditions and prognosis of vascular lesion in patients with T2DM.