精原干细胞去分化和多能性的研究进展

Updated Dedifferentiation and Pluripotency of Spermatogonial Stem Cells

精原干细胞是具有终身有丝分裂能力进行自我复制同时也可分化成单倍体精子的生殖细胞。最近,一些研究发现精原干细胞可在体外被诱导成多能干细胞。提示精原干细胞可成为再生医学所需多能干细胞的很好来源,尤其是获得没有免疫排斥、患者自身来源的多能干细胞。本综述将重点介绍目前对精原干细胞多能性的认识及其在再生医学中应用的优势。

Spermatogonial stem cells （SSCs） are the postnatal mitotic male germ cells that undergo self-renewing and differentiate into haploid sperm through spermatogenesis throughout life time. However, some recent interesting studies indicate that pluripotent cells can be derived from SSCs in culture. Thus, it seems that SSCs are a great resource of pluripotent cells for regenerative medicine, especially to meet the demand of immuno-rejection free pluripotent cells derived from patients themselves. This article aims to introduce the current understanding and advantages of the pluripotent SSCs in regenerative medicine.