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Muc-1 mRNA和CD44 mRNA在非小细胞肺癌组织中的表达及与预后的关系

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摘要 目的探讨Muc-1 mRNA和CD44 mRNA在非小细胞肺癌(NSCLC)组织中的表达情况与淋巴结转移的相关性及其与预后的关系。方法应用RT-PCR方法检测36例NSCLC组织中和10例正常肺组织中Muc-1 mRNA和CD44 mRNA的表达情况。结果①36例NSCLC组织中有19例Muc-1 mRNA阳性表达,阳性表达率为52.7%;21例CD44 mRNA表达,阳性表达率为58.3%。②Muc-1 mRNA在NSCLC组织中的阳性表达与患者的年龄、性别、组织学类型、TNM分期、肿瘤大小无关(P>0.05),与淋巴结转移有关(χ2=10.166,P<0.05);CD44 mRNA在NSCLC组织中的阳性表达与患者的年龄、性别、组织学类型、TNM分期、肿瘤大小无关(P>0.05),与淋巴结转移有关(χ2=8.371,P<0.05)。③Muc-1 mRNA和CD44mRNA阳性表达与NSCLC患者的预后有关(P<0.05)。④Muc-1 mRNA和CD44 mRNA在NSCLC组织中表达成正相关(r=0.442,P<0.05)。结论Muc-1 mRNA和CD44 mRNA阳性表达的NSCLC患者淋巴结转移率高,对NSCLC患者预后判断具有一定的指导作用。
作者 吴勇 李光虎 刘国津 尹光浩 刘伟
机构地区 吉林大学第一医院胸外科
出处 《中国老年学杂志》 CAS CSCD 北大核心 2009年第10期1239-1242,共4页 Chinese Journal of Gerontology
基金 中-加大学合作项目资助课题(SULCP010#)
关键词 MUC-1 CD44 非小细胞肺癌 预后
分类号 R734.2 [医药卫生—肿瘤]
  • 相关文献

参考文献15

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中国老年学杂志
2009年 第10期

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