美罗培南与8种特殊输液的配伍稳定性研究

A stability study on compatibility of meropenern within 8 special infusion solutions

目的全面考察美罗培南与复方电解质葡萄糖(M3A、M3B、MG3、R2A和R4A)注射液、复方乳酸钠林格注射液(SLR)、复方乳酸钠葡萄糖注射液(SLG)和复方乳酸钠山梨醇注射液(SLS)的配伍稳定性。方法配伍溶液室温放置8h后用HPLC法测定美罗培南的含量变化,同时观察配伍溶液外观、不溶性微粒及pH值,并进一步考察不稳定因素。结果配伍溶液的外观和pH值无明显变化,不溶性微粒符合药典规定,药物含量下降则差异较大。结论临床上美罗培南与输液的配伍使用需根据情况区别对待。

Objective This paper studies the stability of meropenem mixed with M3A, M3B, MG3, R2A, R4A, SLR, SLG and SLS infusion solutions to provide a scientific basis for the clinical chemotherapy. Methods Use HPLC to determine the quantities of meropenem in mixture at room temperature and observe their external appearance, pH and the number of insolubility paticles at the same time. Results The appearance and pH of compatible solutions change very little and the number of insolubility particles are also consistent with Chinese Pharmacopeia in 8 hours at room temperature, but the content decrease are different. Conclusion It should be careful to combine meropenem with 8 infusion solutions in clinic.