乳腺癌中基因BCSG1和C-erbB2的表达及意义

Expression and clinical significance of BCSG1 and C-erbB2 protein in the breast cancer

目的了解乳腺癌中乳腺癌特异性基因1(BCSG1)和C-erbB2表达概况,探讨BCSG1和C-erbB2在乳腺癌中表达水平及意义。方法用免疫组化方法检测40例乳腺癌患者中BCSG1和C-erbB2的表达。结果40例乳腺癌组织中阳性表达26例,占65%,40例正常乳腺组织均呈阴性表达,两者比较差异有统计学意义(P<0.05)。乳腺癌组织中BCSG1阳性表达与腋窝淋巴结转移、TNM分期、复发和转移有关(P<0.05)。40例乳腺癌组织中C-erbB2蛋白阳性表达率为37.5%(15/40),正常乳腺组织中均为阴性表达;两者比较差异有统计学意义(P<0.05)。乳腺癌组织中C-erbB2阳性表达与腋窝淋巴结转移、TNM分期、复发和转移有关(P>0.05)。结论基因BCSG1和C-erbB2表达异常是乳腺癌产生的机制之一,与乳腺癌的发生及发展有关。BCSG1可能是乳腺癌的一个重要预后指标。

Objective To study the expression of gene BCSG1 and C - erbB2 and to demonstrate the relationship between the expression of gene BCSG1 and C - erbB2 in breast cancer and to evaluate their clinical siguificances. Methods Inmmunohisto-chemistry method was used to analyze the expression of gene BCSG1 and C - erbB2 in the breast cancer. Results BCSGI was significantly overexpressed in breast cancer compared with its normal mucosa （ P 〈 0.05 ）, and it was related to lymph metastasis and recurrence（ P 〈0.05）. No expression of C - erbB2 was observed in normal tissue. The positive rate of C - erhB2 in breast cancer was 37.5% and it was not related to lymph metastasis and recurrence（ P 〉 0. 05 ）. Conclusion Our date indicate that positive expression of BCSG1 and C - cerbB2 are involved mainly in breast carcinogenesis and BCSG1 was associated with prognosis of breast cancer.