TNT作业工人和HBsAg阳性者血清SOD活性的变化

Changes of superoxide dismutase activity in serum of TNTexposed workers and HBsAg positive workers

对河南某化工厂三硝基甲苯（ＴＮＴ）作业工人劳动卫生学调查结果发现，车间空气中ＴＮＴ浓度多数均超过国家最高容许浓度（ＭＡＣ＝１ｍｇ／ｍ３），工人皮肤污染较严重。超氧化物歧化酶（ＳＯＤ）活性测定结果表明，ＴＮＴ接触组和ＨＢｓＡｇ阳性者均高于对照组，推测ＴＮＴ和ＨＢＶ诱发肝损伤机理可能部分归因于活性氧生成。

The result of occupational investigations in the plantoperating trinitrotoluene (TNT) in Henan province showed that the TNT concentration in air of the workplaces mostly exceeded the national maximum allowable concentration (MAC=1 mg/m3) and the skin of the TNTexposed workers appeared to be severely contaminatedThe activities of serum ALT,AST and positive rate of HBsAg in both exposed and control group showed no significant differencesHowever,activities of serum superoxide dismutase(SOD) of both TNTexposed and HBsAg workers increased significantly in comparison with those of controlIt seemed to exert certain relationship between mechanism of liver damage induced by TNT and HBV and active oxygen generation