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高血压大鼠血浆尾加压素Ⅱ、NO、NOS变化及坎地沙坦干预的影响 被引量:3

高血压大鼠血浆尾加压素Ⅱ、NO、NOS变化及坎地沙坦干预的影响
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摘要 目的:探讨高血压大鼠血浆尾加压素Ⅱ(UⅡ)、NO、NOS变化及坎地沙坦对其影响。方法:WKY大鼠30只,为正常对照组;SHR大鼠60只随机分为对照组与坎地沙坦组,每组30只,测定血浆UⅡ、一氧化氮(NO)、一氧化氮合酶(NOS)水平。结果:①SHR大鼠血浆UⅡ水平明显升高,但血浆NO、NOS水平明显降低;②坎地沙坦可降低血浆UⅡ水平,升高血浆NO、NOS水平;③SHR大鼠组,血浆UⅡ水平分别与NO、NOS水平呈负相关,相关系数分别-0.45,-0.49(P<0.05)。结论:在高血压的发病过程中,血浆UⅡ水平升高,同时伴有血浆NO、NOS水平降低,血浆UⅡ水平与NO、NOS水平具有负相关性。
出处 《中国应用生理学杂志》 CAS CSCD 北大核心 2009年第2期194-195,263,共3页 Chinese Journal of Applied Physiology
基金 河北省科技研究与发展计划项目(06276102D-75)
关键词 高血压 尾加压素Ⅱ 内皮功能 坎地沙坦 hypertension urotensin Ⅱ endothelial function candesartan
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