中药口服制剂致肾损害619例分析

Renal Lesion Induced by Oral Preparations of Traditional Chinese Medicines:Analysis of 619 Cases

目的:为临床合理用药提供参考。方法:检索1991年1月～2008年12月中国期刊全文数据库(CNKI),查找中药口服制剂致肾损害的临床报道,对相关文献、资料进行整理、分析、比较。结果:有相关文献报道176篇,共计病例619例,发生肾损伤原因为长期反复用药、超剂量用药等。结论:应重视中药口服制剂的肾毒性,临床应加强其合理利用,对长期服用该类制剂的患者应定期检查肾功能。

OBJECTIVE： To analyze the renal lesions induced by oral preparations of traditional Chinese medicines so as to provide theoretic basis for clinical rational drug use. METHODS： The CNKI full- text database between January 1991 and December 2008 were retrieved for clinical reports of renal lesions induced by oral preparations of traditional Chinese medicines. And the pertinent literature was sorted, analyzed and compared. RESULTS： 176 reports （totaled 619 cases） were collected. Repeated long - term medication and overdosing etc were the major factors accountable for the renal lesion. CONCLUSION ： Importance should be attached to the nephrotoxicity of oral preparations of traditional Chinese medicines, and which should be used rationally in the clinic and periodic examination of patients＇ renal function should be performed in taking oral preparations of traditional Chinese medicines.