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发展含B-和T-细胞表位嵌合肽疫苗的新趋势 被引量:3

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摘要 在免疫学和疫苗学界最近发展形成了嵌合肽疫苗策略,即作为理想的免疫原,合成分子将一并包含目的抗原B细胞表位和自身或外源非选择性T细胞表位。它不仅继承原单一表位合成肽的全部长处,而且具有不必再与大分子载体偶联,尤其可克服MHC遗传限制,在基因背景各异人群中产生广泛有效免疫应答等显著优点,从而为各类疫苗的研制以及推广应用展现出新的途径和前景。本文概述了嵌合肽的基本原理、它的设计要点和包括抗生育疫苗在内的相关研究实例。
作者 徐万祥
出处 《国外医学(计划生育分册)》 1998年第1期12-16,共5页
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