成人急性淋巴细胞白血病中枢神经系统白血病的预防与治疗
摘要
随着对成人急性淋巴细胞白血病(acute lymphoblastic leukemia,ALL)生物学特性的认识,治疗方法的不断改进,总的完全缓解率已经达到60%~90%。但长期生存率却不令人满意,疾病的复发成为治疗中的一个重大问题。中枢神经系统(central nervous system,CNS)是成人急性淋巴细胞白血病髓外最常见的受累部位之一。初诊时伴有CNS受累的成人ALL患者不到10%,由于CNS受累多数是在患者死后解剖时发现,之前他们只被认为骨髓受累,这个数据可能被低估。
出处
《国际输血及血液学杂志》
CAS
2009年第3期208-212,共5页
International Journal of Blood Transfusion and Hematology
参考文献31
-
1Lazarus HM, Richards SM, Chopra M, et al. Central nervous system involvement in adult acute lymphoblastic leukemia at diagnosis: results from the international ALL trial MRC UKALL XII/ECOG E2993. Blood, 2006, 108(2)~ 465-472.
-
2Reman O, Pigneux A, Huguet F, et al. Central nervous system involvement in adult acute lymphoblastic leukemia at diagnosis and/or at first relapse: results from the GET-LALA group. Leuk Res, 2008, 32(11):1741-1750.
-
3Stewart DJ, Keating MJ, McCredie KB, et al. Natural history of central nervous system acute leukemia in adults. Cancer, 1981, 47 (1): 184-196.
-
4Gokbuget N, Hoelzer D. Meningeosis leukaemica in adult acute lymphoblastic leukaemia. J Neurooneol, 1998, 38 (2-3) :167-180.
-
5Pui CH, Howard SC. Current management and challenges of malignant disease in the CNS in paediatric leukaemia. Lancet Oncol, 2008, 9(3):257-268.
-
6Mahmoud HH, Rivera GK, Hancock ML, et al. Low leukocyte counts with blast cells in cerebrospinal fluid of children with newly diagnosed acute lymphohlastic leukemia. N Engl J Med, 1993,329 (5):314-319.
-
7Mavlight GM, Stuckey SE, Cabanillas FF, et al. Diagnosis of leukemia or lymphoma in the central nervous system by beta 2 microglobulin determination. N Engl J Med, 1980,303 (13) : 718 722.
-
8Kersten MJ, Evers LM, Dellemijn PL, et al. Elevation of cerebrospinal fluid soluble CD27 levels in patients with meningeal localization of lymphoid malignancies. Blood, 1996,87 ( 5 ) : 1985- 1989.
-
9Januszkiewicz DA, Nowak JS. Molecular evidence for central nervous system involvement in children with newly diagnosed acute lymphoblastic leukemia. Hematol Oncol, 1995,13 (4):201-206.
-
10Sancho JM, Ribera JM, Oriol A, et al. Central nervous system recurrence in adult patients with acute lymphoblastic leukemia: frequency and prognosis in 467 patients without cranial irradiation for prophylaxis. Cancer, 2006,106(12) :2540-2546.
-
1神经系统常见肿瘤治疗指引(CSNO 2010)[J].中国神经肿瘤杂志,2010,8(1):58-63.
-
2Horger M,Schulze M,Mroue A,Nagele T,Ernemann U,徐安辉(译),胡道予(校).原发性中枢神经系统淋巴瘤的影像诊断[J].放射学实践,2009,24(1):111-113. 被引量:5
-
3秦坤明.原发性中枢神经系统淋巴瘤15例[J].广西医科大学学报,2003,20(5):780-781.
-
4刘元水.氩氦刀给肺癌患者更多希望[J].家庭健康(医学科普),2011(1):46-46. 被引量:1
-
5李槐.中晚期肝癌患者TACE治疗的探索[J].肝癌电子杂志,2014,1(2):8-12. 被引量:2
-
6刘畅,许春伟,张立英,张岩.原发性中枢神经系统非霍奇金淋巴瘤临床分析[J].临床与病理杂志,2016,36(7):909-913. 被引量:1
-
7张荣恒.CT、MRI在诊断PCNSL中的价值与影像特点分析[J].中国CT和MRI杂志,2015,13(7):113-115. 被引量:5
-
8刘征,徐国政.胶质瘤相关循环生物标志物的研究进展[J].中国临床神经外科杂志,2017,22(3):201-203. 被引量:6
-
9张玉荣,王建军.中药对于子宫癌放射性损伤的治疗作用[J].中国保健营养(下半月),2012,0(5):1635-1635.
-
10张建文,吴敬波.原发性中枢神经系统肿瘤颅外转移状况[J].肿瘤防治研究,2012,39(2):238-240. 被引量:2