成人急性淋巴细胞白血病的MRD动态监测指标及时机
摘要
经过现代的综合治疗方案，成人急性淋巴细胞白血病（ALL）患者也可取得80％以上的完全缓解（CR）率，与儿童ALL的CR率基本接近；但5年的总体生存率则仅30％～40％，远逊于儿童ALL，复发是影响其长期生存的最主要原因。对微小残留病（MRD）的动态监测有助于我们了解患者体内的肿瘤负荷，对疾病缓解质量和复发几率的判断具有重要的预测价值，已经成为评价ALL患者预后的最重要因素之一。该文综述了在成人ALL患者中MRD的检测标记以及不同时间点的MRD监测对预后的判断价值。
出处
《国际输血及血液学杂志》
CAS
2009年第3期217-220,共4页
International Journal of Blood Transfusion and Hematology
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