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以Ig／TCR基因重排为靶目标检测微小残留白血病的研究进展 被引量：1

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摘要 微小残留白血病（MRD）是引起白血病复发的主要原因，准确检测MRD对判断预后、评价疗效、监测复发和指导治疗都具有十分重要的意义。免疫球蛋白／T细胞抗原受体（immunoglobulin／T cell receptor，Ig／TCR）基因重排具有高特异性和高发生率，是检测白血病MRD的分子基础。目前，国际上已建立了基于Ig／TCR基因重排、多中心、大样本、结合临床的实时定量聚合酶链反应监测标准，为临床上判断MRD水平并据此确定治疗方案提供了指导。本文就近年来以Ig／TCR基因重排作为MRD检测靶目标的研究进展作一综述。
作者 李彦媚(综述) 叶铁真(审校)
机构地区 广州市妇女儿童医疗中心血液肿瘤科
出处 《国际输血及血液学杂志》 CAS 2009年第3期229-232,共4页 International Journal of Blood Transfusion and Hematology
关键词 白血病 微小残留白血病 Ig/TCR基因重排 实时定量聚合酶链反应
分类号 R733.4 [医药卫生—肿瘤] R273.37 [医药卫生—中西医结合]
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参考文献17

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二级参考文献14

共引文献9

同被引文献15

  • 1何映谊,叶铁真.PCR检测儿童微小残留白血病的研究进展[J].中国实验血液学杂志,2007,15(3):652-656. 被引量：3
  • 2崔蕾,李志刚,高超,吴敏媛.儿童急性淋巴细胞白血病IgH基因重排的定量检测研究[J].中华检验医学杂志,2007,30(10):1119-1122. 被引量：4
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  • 9Pongers-Willemse M J, Seriu T, Stolz F, et al. Primers and protocols for standardized detection of minimal residual disease in acute lymphoblastic leukemia using immunoglobulin and T cell receptor gene rearrangements and TALl deletions as PCR targets. Report of the Biomed-1 Concerted Action : Investigation of minimal residual disease in acute leukemia. Leukemia, 1999. 13(1): 110-118.
  • 10van Dongen JJ, Langerak AW, Briiggemann M, et al. Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936. Leukemia, 2003, 17 (12) : 2257-2317.

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国际输血及血液学杂志
2009年 第3期

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