葡萄糖依赖性促胰岛素分泌多肽与肥胖

Glucose-dependent insulinotropic peptide and obesity

葡萄糖依赖性促胰岛素分泌多肽(G IP)是十二指肠及空肠上段合成、分泌的一种胃肠道激素。G IP被认为是肠促胰岛素轴中主要肠促胰岛素激素,除了调控胰岛素分泌外,G IP具有促进脂肪细胞成熟分化、对营养物质的吸收及脂蛋白酯酶(LPL)的活性等作用。已经证实G IP在肥胖的发生发展中起着重要的作用。近来研究发现抑制G IP信号转导通路能够治疗肥胖,为肥胖的预防和治疗提供了新的靶点。

Glucose-dependent insulinotropic peptide （GIP）, the gastrointestinal hormone, is synthesized and released from the duodenum and proximal jejunum. GIP is considered to be one of the principle incretin factors of the enteroinsular axis. In addition to its role as the primary mediator of the enteroinsular axis, GIP has the physiological effect on enhancing adipocyte development, nutrient uptaking into adipoeytes, and lipoprotein lipase （LPL） activity in adipocytes. GIP has been shown to play a role in the pathogenesis of obesity. Recent research suggests that inhibition or ablation of the GIP signal prevents obesity. It offers a new latent target to prevent and treat obesity.