帕金森病合并轻度认知功能损害诊断的研究进展

Development in diagnosis of mild cognitive impairment in Parkinson′s disease

帕金森病是老年人常见的神经变性疾病之一,该病患者认知功能损害很普遍。帕金森病合并轻度认知损害是指介于正常认知功能与痴呆之间的过渡状态,是痴呆发生的高危因素。本文介绍帕金森病合并轻度认知损害的定义、神经心理学检测、影像学和生物学指标等方面的进展。

Parkinson＇s disease（PD） is one of the most common neurodegenerative disorders in old people, and in which cognitive impairment is common. Mild cognitive impairment in Parkinson＇s disease（PD-MCI） refers a transitional stage between PD patients with normal cognitive and PD patients with dementia. Some studies have indicated that mild cognitive impairment is a risk factor for dementia in PD. The concept, brief neuropsychological test, imageology manifestation and biomarkers about PD-MCI were reviewed in this article.