肾母细胞瘤中微血管计数的临床意义

The Significance of Microvessel Count in Nephroblastoma

目的：探讨肿瘤内微血管计数（ＭＶＣ）在肾母细胞瘤中的意义。方法：应用免疫组化染色对３８例肾母细胞瘤进行回顾性研究。结果：①预后差的间变型较预后好的各型ＭＶＣ均显著增高（Ｐ＜０．０５），胚芽型较上皮型ＭＶＣ亦显著增高（Ｐ＜０．０５）。②晚期病例较早期者ＭＶＣ显著增高（Ｐ＜０．００１）。③生存组与死亡组ＭＶＣ有显著差异，前者较低（Ｐ＜０．００１）；高ＭＶＣ组较低ＭＶＣ组的生存率明显降低（Ｐ＝０．００１６）。④随肿瘤内炎细胞浸润程度的增加，ＭＶＣ无显著变化（Ｐ＞０．０５）。结论：ＭＶＣ是判断肾母细胞瘤预后一较理想的指标。

Objective: To study the significance of microvessel count (MVC) in nephroblastoma. Methods: MVC was retrospectively measured in 38 cases of nephroblastoma by SP procedure. Results: 1. MVC of nephroblastoma with unfavourable histology was significantly higher than that with favourable histology (P<0.05) and MVC of blastemal type was significantly higher than that of epithelial type (P<0.05). 2. MVC of nephroblastoma of late stage was significantly higher than that of early stage (P<0.001). 3. MVC of the survivals was significantly lower than that of the death (P=0.0016). 4. MVC of tumors with increased infiltration of inflammatory cells showed no significant change (P>0.05). Conclusion: MVC is an indicator of the prognosis of patients with nephroblastoma.