雷公藤微囊长期毒性的实验病理研究

Experimental pathological study on the chronic toxityof microcapsule of tripterygium wilfordii hook F

目的研究雷公藤微囊（ＴＷＨ）的长期毒性。方法采用大鼠和犬，经连续３个月口服给药，动物尸解作大体观察，并取动物脏器行病理组织学检查。结果小剂量ＴＷＨ对大鼠和犬无明显毒性；中剂量使用对肺、肾、肝、脾可产生一定的毒性损害；大剂量可使鼠和犬多个脏器，尤其是肝、肾、脾、胸腺、肺、胃肠道等产生严重病理损害，上述毒性损害于停药后基本可以恢复，也无新的毒性作用出现。结论ＴＷＨ长期低剂量使用对肝、肾无明显毒理作用。

Objective To investigate the chronic toxity of microcapsule of tripterygium wilfordii hook F(TWH) Methods Rats and dogs were administered (ig) TWH for 3 months The animals were killed and observed on macropathology and the organs were histologically examed Results There was no obvious toxity in low dose group; The toxity to lung, kindney, spleen, and liver was observed in middle and large dose groups In addition, the pathological injury was observed in the large dose group The above changes could restore to normal after stoping giving TWH Conclusion TWH, administered chronically at low dose, had no significant toxity and the immunosupressive effect was conformed by pathology