摘要
目的研究雷公藤微囊(TWH)的长期毒性。方法采用大鼠和犬,经连续3个月口服给药,动物尸解作大体观察,并取动物脏器行病理组织学检查。结果小剂量TWH对大鼠和犬无明显毒性;中剂量使用对肺、肾、肝、脾可产生一定的毒性损害;大剂量可使鼠和犬多个脏器,尤其是肝、肾、脾、胸腺、肺、胃肠道等产生严重病理损害,上述毒性损害于停药后基本可以恢复,也无新的毒性作用出现。结论TWH长期低剂量使用对肝、肾无明显毒理作用。
Objective To investigate the chronic toxity of microcapsule of tripterygium wilfordii hook F(TWH) Methods Rats and dogs were administered (ig) TWH for 3 months The animals were killed and observed on macropathology and the organs were histologically examed Results There was no obvious toxity in low dose group; The toxity to lung, kindney, spleen, and liver was observed in middle and large dose groups In addition, the pathological injury was observed in the large dose group The above changes could restore to normal after stoping giving TWH Conclusion TWH, administered chronically at low dose, had no significant toxity and the immunosupressive effect was conformed by pathology
出处
《安徽医科大学学报》
CAS
1998年第3期173-175,共3页
Acta Universitatis Medicinalis Anhui
关键词
雷公藤
毒性
微型胶囊
病理学
大鼠
狗
tripterygium wilfordii/toxicity
micro encapsulate
liver/pathol
kidney/pathol
spleen/pathol
thymus gland/pathol
lung/pathol
gastrointestinal system/pathol
rats
dogs