致心律失常电生理机制探讨
被引量:2
Mechanism of proarrhythmia
摘要
抗心律失常药物既可治疗心律失常,又可诱发心律失常。在治疗剂量范围内抗心律失常药物使已有的心律失常加重或诱发新的心律失常,此谓致心律失常(proarrhythmia),如药物过量引起者为中毒表现。
出处
《中华心律失常学杂志》
2009年第2期123-125,共3页
Chinese Journal of Cardiac Arrhythmias
参考文献9
-
1Choy AM, Darbar D, Dell'Otto S, et al. Exaggerated QT prolongation after cardioversion of atrial fibrillation. JACC, 1999,34: 396- 401.
-
2Mitehenson JS,Chen J, Lin M,et al. A structural basis for drug-induced long QT syndrome. Proc Natl Acad Sci USA, 2000,97: 12329-12333.
-
3Fernandez D, Ghamta A, Kaufman GW, et al. Physieochemical features of the HERG channel drug binding site. J Biol Chem,2004, 279:10120-10127.
-
4Antzelevitch C, Sicouri S, Litovsky SH, et al. Heterogeneity within the ventricular wall. Electrophysiology and pharmacology of epicardial,endocardial and M cells. Circ. Res, 1991,69:1427-1449.
-
5Priori SG,Corr PB. Mechanisms underlying early and delayed after depolarization induced by catecholamine. Am J physiol, 1990,258 : H1796-H1805.
-
6Priori SG, Napolitano C. Genetic defects of cardiac ion channels. The hidden substrate for torsades de pointes. Cardiovasc Drugs Ther,2002.16 :89-92.
-
7Balser JR. The cardiac sodium channel. Gating function and molecular pharmacology. J Mol Cell Cardiol, 2001,33:599-613.
-
8Bezzina CR, Shimizu W, yang P, et al. Common sodium channel promoter haplotype in asian subjects underlies variable in cardiac conduction. Circulation,2006,113 : 330-332.
-
9Reuter H, Henderson SA, Han T,et al. Knockout mice for pharmalogical screening:testing the specificity of Na^+ -Ca^2+ exchanger hibitors. Circ Res,2002,91:90-92.
同被引文献28
-
1单宏丽,潘振伟,冯铁明,许超千,吕延杰,谷瑞民,杨宝峰.奎尼丁诱发心律失常的机制研究[J].中国地方病学杂志,2007,26(1):33-35. 被引量:2
-
2吴俊峰,张耀森,李国鹏,段俊峰,邓睿华,黄颖雯.非心脏开胸手术后心律失常高危因素分析及防治对策[J].中华心律失常学杂志,2007,11(3):222-223. 被引量:3
-
3常秀军,王子彤,韩鸣,杨声,秦明,段勇.795例肺癌术后发生心律失常危险因素的多因素回顾分析[J].中国肿瘤,2007,16(8):633-635. 被引量:20
-
4Podrid PJ. Aggravation of arrhythmia by antiarrhythmic drugs (proarrhythmia) [J]. Cardiac Eiectrophysiol Clin, 2010,2 (3) : 459-462.
-
5吴孟超;孙衍庆.现代手术并发症学[M]西安:世界图书出版西安公司,2003501-504.
-
6Walsh SR,Tang T,Wijewardena C. Postoperative arrhythmias in general surgical patients[J].Annals of the Royal College of Surgeons of England,2007.91-95.
-
7Brathwaite D,Weissman C. The new onset of atrial arrhythmias following major noncardiothoracic surgery is associated with increased mortality[J].Chest,1998.462-468.
-
8Polanczyk CA,Goldman L,Marcantonio ER. Supraventricular arrhythmia in patients having noncardiac surgery:clinical correlates and effect on length of stay[J].Annals of Internal Medicine,1998.279-285.
-
9Bramer S,van Straten AH,Soliman HM. The impact of newonset postoperative atrial fibrillation on mortality after coronary artery bypass grafting[J].Annals of Thoracic Surgery,2010.443-449.
-
10Walker WS,Codispoti M,Soon SY. Long-term outcomes following VATS lobectomy for non-small cell bronchogenic carcinoma[J].European Journal of Cardio-Thoracic Surgery,2003,(3):397-402.doi:10.1016/s1010-7940(02)00814-x.
引证文献2
-
1王小文,黄春,葛明建,汪斌,向小勇.胸腔镜手术与传统开胸术后心律失常发生率的前瞻性对比研究[J].中华胸心血管外科杂志,2013,29(1):4-7. 被引量:13
-
2王小川,谢晓慧,陆浩,史录文.抗心律失常药物致心律失常作用的文献分析[J].中国医院药学杂志,2013,33(21):1825-1826. 被引量:26
二级引证文献39
-
1陈绍华,朱钰.胸腔镜治疗老年肺癌的临床价值[J].临床肺科杂志,2014,19(5):883-885. 被引量:5
-
2崔佳佳,陈必勤,余茂强,张俐.自拟宁心汤治疗老年频发室性早搏30例临床观察[J].云南中医中药杂志,2014,35(8):49-50. 被引量:3
-
3高军,李东涛,何振波,张福维.胸腔镜下肺叶切除术与常规开胸术治疗早期周围型肺癌的疗效对比[J].中国肿瘤临床与康复,2014,21(9):1068-1070. 被引量:7
-
4杜文婷,何立人,刘萍.应用益气养阴清心安神法治疗快速性心律失常概况[J].中医杂志,2014,55(23):2057-2060. 被引量:11
-
5屈灿,王小文,黄春,向小勇,邱峰,吕志前.硫酸镁预防肺叶切除术后房颤的前瞻性队列研究[J].上海交通大学学报(医学版),2015,35(4):554-558. 被引量:2
-
6李立彬,高妍,李栋,郑江敏,郭志刚.电视胸腔镜和开胸肺叶切除术治疗老年早期肺癌患者的疗效及安全性比较[J].临床合理用药杂志,2015,8(14):112-113. 被引量:5
-
7姜文军,刘思洋,田野,赵希彤,王晴,田大力.VATS、微创小切口与常规开胸肺叶切除术对患者围术期肺功能的影响[J].医学临床研究,2015,32(10):1900-1902. 被引量:5
-
8张丽梅,胡元会.室性早搏的中西医治疗进展[J].世界中医药,2015,10(10):1626-1630. 被引量:31
-
9赵琪,汪溪洁,王淑颜,马璟.基于人胚胎干细胞的实时细胞系统评价心脏毒性方法的建立[J].中国药理学通报,2016,32(1):138-143. 被引量:5
-
10袁鹏英,张庆华,杨坤杰,黄敏.复脉定胶囊“病证-方药-效应”关联性研究[J].亚太传统医药,2016,12(4):62-65. 被引量:2
-
1糖尿病合并甲减易发低血糖[J].健康必读(健康新语),2013(5):60-60.
-
2陈振安.长托宁治疗有机磷中毒的体会[J].齐齐哈尔医学院学报,2010,31(19):3091-3091.
-
3周玉淑.血药浓度监测在预防和判断药物过量与中毒方面的临床应用[J].急诊医学,1993,2(3):148-149.
-
4王艳.肺血栓栓塞症的抗凝治疗[J].中国社区医师,2016,32(6):20-21.
-
5崔利军,高良会.多虑平过量致意识障碍伴心动过速一例报告[J].河北精神卫生通讯,1989,2(1):53-53.
-
6杜军.2005-2006年度各种中毒或药物过量95例急诊临床分析[J].世界急危重病医学杂志,2007,4(6):2141-2142.
-
7杨黎红.急诊低血糖昏迷临床分析[J].医药论坛杂志,2004,25(8):19-20.
-
8Shenfield G M,张金山.药物过量的处理[J].临床荟萃,1990,5(3):126-128. 被引量:1
-
9程廉,陶玉玲,李连明.过量普罗帕酮致室性心动过速合并休克1例[J].江西医药,2003,38(5):383-383.
-
10宋继育,潘建章.抗精神病药过量对心电图的影响[J].临床精神医学杂志,2001,11(4):215-216. 被引量:7