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肿瘤坏死因子-α基因多态性与严重急性呼吸综合征愈后肺纤维化及股骨头坏死的关系

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摘要 TNF—α是炎性反应的关键性细胞因子,在早期有促进康复、限制炎性反应发展的作用。但TNF—α的过量表达,可能造成疾病预后不良。SARS患者治愈后,部分康复者出现肺间质纤维化(interstitial lung fibrosis)改变。前期调查资料显示,200例SARS患者康复后第9个月的肺间质改变患病率为21%。同时,SARS部分康复者出现股骨头坏死(femoral head necrosis),天津的随访资料发现,
出处 《中华传染病杂志》 CAS CSCD 北大核心 2009年第5期301-304,共4页 Chinese Journal of Infectious Diseases
基金 天津市科技攻关重点项目(05YFSZSF02900)
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