1,2-二甲基咪唑啉的合成及表征

Synthesis and Charaterization of 1,2-Dimethylimidazoline

对1,2-二甲基咪唑啉的合成进行了详细研究.以甲胺水溶液和2-溴乙胺氢溴酸盐(1)为原料进行反应,在两种原料物质的量之比为5∶1,缓缓回流12h的条件下,得到N-甲基乙二胺(2),N-甲基乙二胺经过乙酸化得到N-甲基-N,N′-二乙酰基乙二胺(3),然后,N-甲基-N,N′-二乙酰基乙二胺和氧化钙在高温下关环得到1,2-二甲基咪唑啉(4).并对所得到的产物1,2-二甲基咪唑啉经元素分析,1HNMR,IR和GC-MS得到了表征.

Here a convenient and comparatively cheap route to DMI was provided, which includes that （a） N-methyl ethylenediamine （2） was prepared from aqueous methylamine solution and 1-amino-2-bromoethane hydrobromide （1） （molar ratio 5 ： 1） under gentle reflux during 12 h, （b） N-methyl-N,N′-diacetylethylenediamine （3） was obtained via direct acetulation of 2 with acetic acid, and （c） the target molecule 1,2-dimethylimidazoline （4） was prepared by CaO catalyzed cyclization of 3 at elevated temperature. All compounds were characterized by elemental analysis, IH NMR, IR and GC-MS techniques.