动态血压监测在非胰岛素依赖型糖尿病中的应用

Application of ambulatory blood pressure monitor in patients with non-insulin dependent diabetes mellitus

对50例血压正常的非胰岛素依赖型糖尿病（NIDDM）患者进行24h动态血压监测（ABPM）。结果NIDDM组的24h平均舒张压（9．8±1．2kPa）、白天平均舒张压（10．0±1．2kPa）、夜间平均舒张压（9．5±1．2kPa）均比对照组（分别为8．8±1．0、9．1±1．0、8．1±1．1kPa）明显升高，夜间收缩压及舒张压下降百分率均明显降低，昼夜节律消失。有糖尿病肾病组患者眼底视网膜病变发生率高。提示随着血压昼夜节律的消失及夜间血压持续升高，可能导致肾病变及视网膜血管病变的发生。

For investigating the changes of ambulatory blood pressure in patients with diabetes mellitus. 50 non-insulin dependent diabetes mellitus (NIDDM) patients with normal blood pressure and 40 norma1 controls were studied. The results showed that in NIDDM patients as: (1)average 24-h DBP,day time DBP and night time DBP were sighficantly increased compared with those of the controls (P <0. 01 ), (2)the percentage of reduction in night time SBP and DBP were significantly decreased; (3)the incidence of retinopathy was high in the group with early diabetic nephropathy. It is suggested that circadian variation of blood pressure is disappeared in diabetes and the increase in night time BP may induce diabetic nephropathy and retinopathy.