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经气道应用脂质体携载前列腺素E_1减轻油酸型大鼠肺损伤 被引量：1

Intratracheally Administered Liposomal Prostaglandin E1 Mitigates Oleic AcidInduced Lung Injury In Rats
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摘要 目的研究经气道应用脂质体携载前列腺素Ｅ１（Ｌ－ＰＧＥ１）对油酸所致的大鼠急性肺损伤的保护作用。方法观察肺水肿的程度，测定肺组织碱性磷酸酶（ＡＬＰ）与血管紧张素转换酶（ＡＣＥ）的活性。结果Ｌ－ＰＧＥ１明显降低了损伤大鼠的肺系数（Ｐ＜０．０１）和肺湿重／干重比（Ｐ＜０．０５），显著提高了肺组织的ＡＬＰ（Ｐ＜０．０１）与ＡＣＥ（Ｐ＜０．０５）的活性。Ｌ－ＰＧＥ１的作用明显优于游离的ＰＧＥ１或空白脂质体。结论气道内给予Ｌ－ＰＧＥ１对治疗急性肺损伤具有良好的效果。 bjective To investigate the effects of intratracheally administered liposomeencapsulated prostaglandin E1(LPGE1) on oleic acidinduced acute lung injury in rats.Methods The degree of pulmonary edema and the activities of alkaline phosphatase(ALP) and angiotensin converting enzyme(ACE)of the lung tissues were observed.Results LPGE1 markedly decreased pulmonary coefficient( P<0.01) and rate of lung wet weight/dry weight( P<0.05),and greatly enhanced the activities of ALP( P<0.01)and ACE( P<0.05).The protective role of PGE1 was significantly better than that of free PGE1 or plain liposome.Conclusion:LPGE1,administered intratracheally,may serve as a potentially effective agent in the treatment of acute lung damage.
作者 龚永生 李夏 吴东红 张灵芝 郑绿珍 王卫 唐朝枢 蒋仲荪
机构地区 温州医学院肺心病研究室 北京医科大学心血管基础研究所 浙江师范大学医院
出处 《温州医学院学报》 CAS 1998年第2期91-93,共3页 Journal of Wenzhou Medical College
基金 国家自然科学基金
关键词 脂质体 前列腺素E1 肺损伤 急性 药物疗法 Liposome Prostaglandin E1 Oleic acid Lung injury,cute
分类号 R563.05 [医药卫生—呼吸系统]
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参考文献10

  • 1Leff JA, Ba er JW, Kirkman JM, et al. Liposome-entrapped PGEI posttreatment decreases IL-1 alpha-induced neutrophil accumulation and lung leak in rata. J Appl Physiol,1994,76(1):151.
  • 2Mizushima Y, Yanagawa A, Hoski K. Prostaglandin E,is more effective, when incorporated in lipid microspheres, for treatment of peripheral vascular diseases in man. J Pharm Pharmacal,1983,35:666.
  • 3张灵芝,汤健,唐朝枢,苏静怡.均匀单层脂质体的制备方法[J].基础医学与临床,1992,12(4):253-256. 被引量：12
  • 4Lowry OH,Rosebrough NJ,Farr AL;et al Protein measure ment with the folin phenol reagent. J Biol Chem, 1951, 193:265.
  • 5Suntres ZE and Shek PN. Treatment of LPS-induced tissue injury:role of liposomal antioxidants. Shock, 1996, 6(Supp l):S57.
  • 6景有伶,杨秋,郑俊国,崔和勤,马玉妹.山莨菪碱对油酸致兔急性肺损伤的防治作用[J].中国危重病急救医学,1997,9(1):2-5. 被引量：6
  • 7Fantone JC, Marasco WA, Elgas LG, et al, Stimulus specificity of prostaglandin in hibition of rabbit polymorphonuclear leukocyte lysosomal enzyme release and superoxide anion production.Am J Pathol,1984,115(1):9.
  • 8Scheffler P, Gross J, Markwirth T , et al. Progress in the prostaglandin E: therapy of the intermittent claudication by means of holous injections of LIPAO-prostaglandin El.(LIPO-PGE1) Eur J Clin Pharmacet,1996,51(3-4):239.
  • 9Walther FJ, David-cu R CuR, Lopez SL. Antioxidant-surfactant liposomes mitigate hyperoxic lung injury in premature rabbits,Am J Physoil,1995,269(5 Pt 1):L613.
  • 10Suntres ZE and Shek PN. alleviation of paraquat-induced lung injury by pretreatment with bifunctional liposomes containing alpha-tocopheral and glutathione, Biochem Pharmacol,1996,52(10):1515.

二级参考文献5

共引文献16

同被引文献12

  • 1孙秀弘 李俊成.前列腺素E1对肺的细胞保护作用[J].生理学报,1986,38:397-397.
  • 2景有伶,杨秋,郑俊国,崔和勤,马玉妹.山莨菪碱对油酸致兔急性肺损伤的防治作用[J].中国危重病急救医学,1997,9(1):2-5. 被引量：6
  • 3Smith WG, Thompson JM, Kowalski DL, et al. Inhaled misoprostol blocks guinea pig antigen - induced bronchoconstruction and airway inflammation [ J ]. Am J Respir Crit Care Med, 1996,154:295 - 299.
  • 4Mikawa K, Akamatsu H, Meakawa N, et al. Inhibitory effect of prostaglandin E1 on human neu- trophil function, prostaglandins[J]. Leukot Essent Fatty Acid, 1994,51:287 - 291.
  • 5Leff JA, Baer JW, Kirkmarr, et al. Liopsome - entrapped PGF1 treatment decrease IL- 1 alpha- induced neutrophil accumulation and lung leak in rats[ J ]. J Appl physiol, 1994,76:151 - 157.
  • 6Slanb NC, Ohkada K. PGE1 reveres increased lung microvascular permeability during air emboli[J]. Mierovase Res, 1978,15:271.
  • 7Walmrath WQ, Schneider T, Pilch J, et al. Aerosolized prostacyclin in adult respiratory distress syndrome [ J ].Lancet, 1993,342:961 - 962.
  • 8Leff JA, Bure JW, Kirkman JM, et al. Liposome alpha induced neutrophil accumulation and lung leak in rats[ J]. J Appl Physiol, 1994,76(1) ; 151.
  • 9Shale DL. The adult respiratory distress syndrome - 20 years[J]. Thoras, 1987,42(9) :641.
  • 10Victor L, Schuster. Molecular mechanism of prostsglandin tramsport[ J]. Annual Review tff Physiology, 1998, 60:222.

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温州医学院学报
1998年 第2期

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