肝癌术后复发的影响因素研究

Analysis on the factors for hepatocarcinoma relapse after surgery.

目的探讨肝癌术后复发的影响因素。方法 615小鼠脾包膜下接种肝癌H_(22)腹水瘤细胞制备实验性肝转移模型。在脾接种前后的不同时间进行部分肝切除或假手术,并比较不同程度手术创伤对肿瘤转移的作用。结果假手术组和部分肝切除组与单纯脾接种组比较均对肿瘤转移起促进作用,其中又以部分肝切除促肿瘤转移效应最显著,1/3肝切除显著于1/4肝切除。手术促肿瘤转移的时间以术后3天内最显著。结论手术创伤尤其是部分肝切除对肝癌转移起促进作用,并与转移程度呈正相关关系。

Objective To detect the influence of the surgical trauma on hepatocarcinoma metastasis. Methods A mouse model of experimental liver cancer metastasis by inoculation hepatoma 22 (H_(22)) into spleen sub- serous layer of 615 mice was adopted. The partial hepatectomy or sham operation was performed at vari- ous periods of spleen inoculation, and metastasis effect was observed. Results Compared to single spleen inoculation, the significant metastasis-augmenting effect was observed in partial hepatectomy group, with that in 1/3 hepatectomy being more remarkable than in 1/4 hepatectomy. This enhanced effect was found 3 days after surgery. Conclusion Surgical trauma, especially partial hepatectomy, is involved in enhanced metastasis, and there exists significantly positive correlation between the degree of trauma and metastasis-augmenting effect.