川芎嗪对急性冠脉综合征患者血清C反应蛋白及血液流变学的影响

Effects of Ligustrazine Hydrochloride Injection on Serum C-reaction Protein and Haemorheology in Patients with Acute Coronary Syndrome

目的:观察川芎嗪注射液(LHI)对急性冠脉综合征(ACS)患者血清C-反应蛋白(CRP)及血液流变学的影响,探讨LHI在稳定冠脉粥样斑块中的作用。方法:本研究采用前瞻性开放性病例对照研究,以248例ACS患者(其中急性心肌梗死(AMI)115例,不稳定心绞痛(UA)133例)及100例健康志愿者为研究对象,与发生ACS48h空腹采静脉血,健康对照组空腹采静脉血,测定血清CRP及血液流变学指标。在248例ACS患者中随机选取100例分为治疗组和对照组:对照组(50例)采用常规治疗;治疗组(50例)在常规治疗的基础上加LHI80mg+5%葡萄糖250ml静脉滴注,一日一次。于治疗10d后检测患者CRP及血液流变学指标。结果:ACS患者血清CRP及血液流变学各指标均显著高于健康对照组(P<0.01);AMI患者血清CRP及血液流变学各指标又显著高于UA组(P<0.01)。经治疗10d后,各组CRP及血液流变学各指标较治疗前均改善,差异有显著性(P<0.01),治疗组血清CRP及血液流变学各指标显著低于对照组(P<0.01)。结论:ACS患者血清CRP增高,血液流变学指标异常。LHI可显著降低ACS患者血清CRP并改善血液流变学指标,提示其有抑制冠脉粥样斑块的炎性反应,稳定斑块,减少心血管不良事件的作用。

Objective： To observe the effects of Ligustrazine Hydrochloride Injection （LHI） on serum C-reactive protein（CRP） and hemorheology in patients with acute coronary syndrome and investigate the stabilization of LHI on coronary atheromatous plaque. Mehtods： This study used the forward-looking open case to compare, 248 patients with acute coronary syndrome （include acute myocardial infarction 115 cases, unstable angina 133 cases） and 100 health volunteer were enrolled. All the patients were phlebotomized 5 ml on an empty stomach in 48 hours after ACS. Health volunteers were phlebotomized 5 ml on an empty stomach. CRP was measured by immunoturbidimetry and hemorheological indexes were determined. Randomly chosen 100 cases from 248 ACS cases and randomly divided into a treatment group and a control group. The control group （50 cases） was treated with conventional therapy, and the treatment group （50 cases） was treated with Ligustrazine Hydrochloride Injection （LHI 80 mg＋ 5% Glucose 250 ml iv gtt, Qd） combined with conventional therapy. The total period of treatment was 14 days. CRP was measured by immunoturbidimetry and hemorheological indexes were determined after the treatment. Results： The CRP and hemorheological indexes of the patients with ACS were significantly higher than health control group （P〈0.01） and the AMI＇s were higher than that of UA＇s （P〈0.05）. Aider treating 10 d, the plasma CRP and hemorheological indexes of all groups＇ were improved significantly than that before treating. And treatment group CRP and hemorheological indexes were obviously lower than the control group （P〈0.01）. Conclusion： The blood serum CRP in patients with ACS was increased and hemorhemology was abnormal. LHI can reduce the CRP and improve the indexes of hemorhemology in the patients with ACS. This suggests that LHI can inhibit the inflammatory reaction of coronary atheromatous plaque and stable it, and reduce the cardiovascular bad event＇s function.