可注射性透明质酸苄基酯凝胶在软骨组织工程中的应用

Application of injectable hyaluric acid phenmethyl ester gelatin in cartilage tissue engineering

软骨组织工程学是关节软骨损伤修复研究的热点,其中生物载体的选择和构建是关键问题。生物材料不仅作为一种细胞生存载体,还要具有体内或异位诱导软骨组织修复和再生的功能。天然的软骨细胞外基质支架的开发有可能成为组织工程化软骨进一步发展的关键,透明质酸凝胶就具备了上述的要求。透明质酸苄基酯是一种在透明质酸凝胶基础上开发的半合成可吸收性生物材料。实验证明它能够为软骨细胞提供三维的生长空间,使其不断增殖的同时,还能够保持固有的表型,脂溶性的增强以及生物作用半衰期的延长,更使其在保持原有流动性优势的情况下,又具备了相对增强的机械强度,是一种更加符合组织工程学要求的生物材料。

The cartilage tissue engineering is a hot spot on reparing articular cartilage injury, while the choice and construction of biological carrier are the key questions. The biological material not only takes one kind of cell survival carrier, but must have the in vivo or the dystopia function to induce repair and regeneration of cartilage tissues. A development of natural cartilage extracellular matrix scaffold will become a key progress to support tissue-engineered cartilage tissues. Hyaluric acid gelatin is satisfactory to the above mentioned requests. The hyaluric acid phenmethyl ester is a half-synthetic absorbable biological material which develops in the hyaluric acid gelatin foundation. The experiment proved that it could provide a three-dimensional growth space for the cartilage cells, cause an unceasing proliferation, maintain the inherent phenotype, induce a fat-soluble enhancement, prolong a biological half life, maintain the original fluid superiority in the situation, and enhance the relative mechanical strength. Therefore, it is an ideal biological material conforms to the tissue engineering requests.