鼻敏片对大鼠变应性鼻炎鼻黏膜ICAM-1、VCAM-1表达的影响

Effect of Bimin Tablet on ICAM-1 and VCAM-1 expression in nasal mucosa of exprimental allergic rhinitis in rats

目的研究鼻敏片对大鼠变应性鼻炎鼻黏膜ICAM-1、VCAM-1表达的影响。方法将SD大鼠先用卵清白蛋白经腹腔内注射致敏,然后鼻腔滴入卵清白蛋白,造成变应性鼻炎模型,随机分为空白对照组、模型组、鼻敏片低剂量组、鼻敏片高剂量组、开瑞坦组各10只,均治疗15 d。结果与空白对照组比,变应性鼻炎各组ICAM-1、VCAM-1的阳性细胞表达数明显增加,差异具有统计学意义(P<0.01);与模型组相比,ICAM-1表达均被鼻敏片和开瑞坦所抑制,差异具有统计学意义(P<0.01);VCAM-1的表达均被鼻敏片高剂量组和开瑞坦组具有抑制作用,差异具有统计学意义(P<0.01)。结论鼻敏片能抑制变应性鼻炎大鼠鼻黏膜ICAM-1、VCAM-1的表达。

Objective TO investigate the effect of Bimin Tablet （BMT） on ICAM-1 （Intercellular adhesion molecule-1） and VCAM-1 （Vascular cell adhesion molecule-1） expression in nasal mucosa of experimental allergic rhinitis in rats. Method SD rats models, immunized by intraperitoneal injection of Ovalbumin（OVA）, then instilled OVA into nasal cavity, were random-Ly divided into four group： allergic rhinitis model group （n=10）; the higher dose group of BMT （n=10）; the lower dose group of BMT （n=10）; Kairuitan treated group （n=10）. All animals were treated for 15 days. Result The number of positive immunoreactive cells（ICAM-1 and VCAM-1） was increased significantly in all the groups compared with normal group （P〈0.01）. ICAM-1 expression was inhibited by giving with Bimin Tablet and Kairuitan comparedwith allergic rhinitis model group（P〈0.01）; VCAM-1 expression was inhibited by giving with Bimin Tablet （especially in the higher dose group of BMT） and Kairuitan comparedwith allergic rhinitis model group （P〈 0.01）. Conclusion Bimin Tablet can decrease the expression of ICAM-1 and VCAM-1 in nasal mucosa of experimental allergic rhinitis.