通痹颗粒联合甲氨喋呤对类风湿性关节炎患者血清IL-6的影响

Effects of Tongbi granules combined with methotrexate on IL-6 in patients with rheumatoid arthritis

目的观察通痹颗粒联合甲氨喋呤对类风湿性关节炎血清IL-6的影响。方法将60例类风湿性关节炎患者随机分为治疗组(30例)和对照组(30例),治疗组予通痹颗粒和甲氨喋呤,对照组予甲氨喋呤,治疗3个月后分别观察两组患者给药前后血清IL-6变化情况。结果治疗组显效率为43.3%,对照组显效率为26.7%,两组比较差异具有统计学意义(P<0.05);治疗组降低血清IL-6水平亦优于对照组,差异具有统计学意义(P<0.05)。结论通痹颗粒联合甲氨喋呤能有效降低血清IL-6水平,改善患者临床症状,是类风湿性关节炎中西医结合治疗的有效方案。

Objective To investigate the effects of combined Tongbi granules（TBG） and methotrexate（MTX） on IL-6 in patients with rheumatoid arthritis（RA）. Methods 60 patients with RA were randomly divided into the test group treated with TBG and MTX, and the control group with only MTX; the changes of IL-6 in two groups before and after three months were observed. Results The effectual rate in test group（43.3%） to reduce the index levels of blood IL-6 was remarkably better than that in control group（26.7%）（P〈0.05）. Conclusion The troatment combined TBG and MTX is effective to reduce the level of serum IL-6, which is an effective therapy for RA.