超微肿痛贴对膝骨性关节炎疗效及关节液中P物质的影响

Curative effect of Chaowei Zhongtongtie for 30 patients with knee osteoarthritis and its effect on P material in synovial fluid

目的观察超微肿痛贴对膝骨性关节炎疗效及关节液中神经肽P物质(P物质)的影响。方法90例膝骨性关节炎患者,随机分为治疗组(超微肿痛贴组)、对照Ⅰ组(传统肿痛贴组)、对照Ⅱ组(狗皮王膏组),10 d为1个疗程。疗程结束后观察其临床疗效;采用ELISA法检测患者膝关节液中神经肽P物质(P物质)浓度的变化。结果治疗组临床疗效和降低P物质浓度均优于对照组,差异具有统计学意义(P<0.01)。结论超微肿痛贴治疗膝骨性关节炎临床疗效较好,降低膝关节液P物质浓度是其作用机制之一。

Objective To investigate the patients with knee osteoarthritis and its effect on curative effect of Chaowei Zhongtongtie for 30 P material in synovial fluid. Methods The 90 patients with knee osteoarthritis were randomly divided into treatment group with Zhongtongtie, control groupl with traditional paster and control group2 Goupiwang sticking plaster, and the clinical efficacy was observed; the substance neuropeptide P （the P material） in knee joint fluid was determined with ELISA method. Results The clinical efficacy and P material in the treatment group were better than that in both two control groups. Conclusions The plaster Zhongtongtie is effective to knee osteoarthritis and maybe, it is one of the action mechanism to re- duce the concentration of P material.