丹参饮化裁治疗原发性贲门失弛缓症24例临床观察

Clinical Observation on the Effect of Modified Danshen Yin on 24 Cases of Primary Achalasia

目的观察丹参饮化裁复方对原发性贲门失弛缓症的疗效。方法对42例原发性贲门失弛缓症患者进行随机对照观察,治疗组24例用丹参饮化裁汤剂治疗,对照组18例用硝苯地平治疗,疗程1周。以吞咽困难、反食、胸骨后疼痛症状评分及X线影像改善情况评价疗效。结果两组患者治疗后吞咽困难、反食症状虽均有不同程度改善,但以治疗组改善吞咽困难、反食效果更加显著。胸骨后疼痛评分两组治疗前后比较差异均有统计学意义(P<0.01),提示两组对胸骨后疼痛症状改善效果均较显著。治疗组临床总有效率为87.5%,对照组为72.2%,治疗组疗效明显优于对照组(P<0.01)。结论丹参饮化裁治疗原发性贲门失弛缓有效,效果优于硝苯地平。

Objective To observe the therapeutic effect of modified Danshen Yin on primary achalasia. Methods The 42 achalasia patients were randomized into two groups. The treatment group, 24 cases, was treated by modified Danshen Yin and the control group, 18 cases, by Nifedipine, for one week. The symptom scores of dysphagia, retrosternal pain and food regurgitation and the improvement of X-ray image were taken to evaluate the therapeutic effect. Results After treatment, both groups had improvement in the symptom scores, but the improvement of treatment group in dysphagia and food regurgitation was more significant. There was a significant difference of both groups in retrosternal pain before and after treatment （P〈0.01）, showing a significant relieve of ret- rosternal pain in both groups. The total effective rate in treatment group was 87.5%, significantly better than that in control group, 72.2% （P〈0.01）. Conclusion Modified Danshen Yin is effective in treating primary achalasia, better than Nifedipine.