解毒祛瘀方治疗寻常型银屑病的临床疗效及对血浆内皮素的影响

Effect of Jiedu Quyu Formula for Psoriasis Vulgaris and Its Influence on Plasma Endothelin

目的研究解毒祛瘀方治疗进展期寻常型银屑病血瘀证临床疗效及作用机理。方法将70例进展期寻常型银屑病患者随机分为两组,治疗组35例用解毒祛瘀方治疗,对照组35例用复方青黛丸治疗;另选30名健康者作为健康组。治疗前后分别测定健康组和两组银屑病患者血浆内皮素(ET)含量;并观察治疗组和对照组的临床疗效。结果两组治疗后皮损面积和严重程度指数(PASI)与治疗前比较均明显降低(P<0.05),治疗2个疗程后治疗组分值明显低于对照组(P<0.05)。治疗组愈显率74.3%,对照组愈显率51.4%,两组比较差异有统计学意义(P<0.05)。治疗组能显著降低血浆ET水平(P<0.01)。结论解毒祛瘀方治疗进展期寻常型银屑病有较好的疗效,且能降低ET水平。

Objective To study the therapeutic effect of Jiedu Quyu Formula （Formula for Removing Toxins and Blood Stasis） on psoriasis vulgaris of progressive stage and its mechanism. Methods The 70 patients of progressive psoriasis vulgaris were randomized into treatment group （35 cases）, treated by Jiedu Quyu Formula, and control group （35 cases）, treated by Compound Qingdai Capsule. Healthy control group was of 30 healthy subjects. The contents of plasma endothelin （ET） were determined before and after treatment respectively, and the therapeutic effect of both treated groups were observed. Results After treatment, the psoriasis area and severity index （PASI） of both treated groups were significantly decreased in comparison with before treatment （P〈0.05）. After two treatment coures, PASI of the treatment group was significantly lower than that of the control group （P〈0.05）. In treatment group, the remarkable effective rate was 74.3%, and in control group, it was 51.4%. The difference was significant （P〈0.05）. There found an obvious decrease of content of ET in treatment group as well （P〈0. 01）. Conclusion Jiedu Quyu Formula is effective for psoriasis vulgaris of progressive stage and functions to decrease the content of ET.