接骨木中木脂素类化学成分研究

Lignans from stems of Sambucus williamsii

目的：研究接骨木Sambucus williamsii茎枝的化学成分。方法：采用60％乙醇提取，经D101大孔吸附树脂、硅胶、Sephadex LH-20，ODS，制备型HPLC等各种现代分离手段，对接骨木中的木脂素类成分进行分离纯化，用波谱学方法对得到的化合物进行结构鉴定。结果：分离得到了7个木脂素类化合物，包括erythro-guaiaeylglyeerol-β-O-4＇-sinapyl ether（1），1-（4＇-hydroxy-3＇-methoxyphenyl）-2-[4”-（3-hydroxy—propyl）-2”，6”-dimethoxyphenoxy]propane-1，3-diol（2），异落叶松树脂醇（3），bursel—ignan（4），lyoniresinol（5），5-甲氧基-异落叶松树脂醇（6），环橄榄树脂素（7）。结论：化合物1—7均为首次从该属植物中分离得到。

Objective： To study the chemical constitutents of the 60% ethanol extract of the stems of Sambucus williamsii. Method： Compounds were isolated and purified by Diaion D101, silica gel, Sephadex LH-20, ODS column chromatography and preparative HPLC. Their structures were identified by spectroscopic methods. Result： Seven lignans were isolated and identified as erythro-guaiacylglycerol-β-O-4 ＇-sinapyl ether （ 1 ）, 1 - （ 4 ＇-hydroxy-3 ＇-methoxyphenyl ） -2- [ 4”- （ 3-hydroxypropyl ） -2”, 6”-dimethoxyphenoxy ] propane-1,3-diol （2）, isolariciresinol （3）, burselignan （4）, lyoniresinol （5）, 5-methoxy-isolariciresinol 6 ）, cycloolivil （7）. Conclusion： All these compounds were obtained from this genus for the first time.