慢性萎缩性胃炎白细胞介素-1β基因多态性研究
摘要
慢性萎缩性胃炎是重要的胃癌前疾病,其发生机制目前并不十分明确。长期以来慢性炎症被认为是慢性萎缩性胃炎最终导致癌变过程中的关键事件,尤其在幽门螺杆菌(Hp)感染患者。白细胞介素(IL)-1不仅是重要的促炎因子,还是胃酸分泌的强力抑制剂,可提高诱导型一氧化氮合酶(iNOS)和环氧合酶-2(COX-2)的生成。并促进或加重胃黏膜损伤。本研究采用SNaPshot技术检测慢性萎缩性胃炎和非萎缩性胃炎患者的IL-1β基因-511、-31、-1473和+3954多个位点多态性以及IL-1RN串连重复多态性,探讨IL-1β基因多态性与慢性萎缩性胃炎的关系。
出处
《中华消化杂志》
CAS
CSCD
北大核心
2009年第5期349-351,共3页
Chinese Journal of Digestion
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