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剪切应力-内皮细胞-Caveolin-1信号通路在动脉粥样硬化中的作用 被引量：9

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摘要 动脉粥样硬化性疾病发病机制复杂且严重危害人类健康。单纯的脂质浸润学说、损伤反应学说、免疫炎症学说等都不能解释一个现象:动脉粥样硬化病变的局部好发性。但一个共同的事实是动脉粥样硬化病变好发的局部都存在血流动力学的异常。血流剪切应力异常是促进动脉粥样硬化病变形成的重要原因。但局部血流动力学变化是如何影响血管壁功能的确切机制尚未阐明,也就是说剪切应力变化与动脉粥样硬化局部好发性的关系并未完全阐明。剪切应力-内皮细胞-Caveolin-1信号通路在动脉粥样硬化形成中有重要作用,本文综述了目前已知血流剪切应力-内皮细胞-Caveolin-1信号通路在动脉粥样硬化中的作用并提出了急需解决的几个问题。
作者 杨琼 武春艳 江璐 刘录山
机构地区 南华大学心血管病研究所动脉硬化学湖南省重点实验室
出处 《中国动脉硬化杂志》 CAS CSCD 北大核心 2009年第3期237-240,共4页 Chinese Journal of Arteriosclerosis
基金 国家自然科学基金(30700325) 动脉硬化学湖南省高校科技创新团队经费资助
关键词 动脉粥样硬化 剪切应力 内皮细胞 Caveolae/Caveolin-1 信号通路
分类号 R363 [医药卫生—病理学]
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参考文献31

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二级参考文献90

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中国动脉硬化杂志
2009年 第3期

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