癫癎和热性惊厥患儿血清褪黑素水平的变化及其临床意义

Serum melatonin levels in children with epilepsy or febrile seizures

目的探讨癫癎和热性惊厥患儿血清褪黑素水平的变化及其临床意义,为褪黑素用于癫癎和热性惊厥的治疗提供依据。方法该研究分为对照组,即上呼吸道感染发热无惊厥患儿;热性惊厥组,其中又分为单纯性热性惊厥(SFS组)和复杂性热性惊厥(CFS组);癫癎组。采用酶联免疫吸附法(ELISA)分别测定各组血清褪黑素水平。结果癫癎和复杂性热性惊厥患儿血清褪黑素水平分别为8.66±1.38和14.91±2.61 ng/L,均显著低于对照组的23.93±2.01 ng/L,差异有显著性(P<0.01),单纯性热性惊厥患儿血清褪黑素水平为20.72±2.54 ng/L,低于对照组,但差异无显著性意义(P>0.05);癫癎患儿血清褪黑素水平明显低于热性惊厥患儿,差异有显著性(P<0.01)。结论癫癎和复杂性热性惊厥患儿血清褪黑素水平降低。补充外源性褪黑素可能是治疗儿童癫癎和热性惊厥的一个新途径。

Objective To study serum levels of melatonin in children with epilepsy or febrile seizures in order to provide a basis for the treatment of epilepsy or febrile seizures with melatonin. Methods Serum melatonin levels were measured using ELISA in 15 children with simple febrile seizure （SFS）, in 15 children with complex febrile seizure （CFS）, in 15 children with epilepsy, and in 15 children with upper respiratory infections （control group）. Results Serum melatonin levels in children with epilepsy （8.66 ± 1.38 ng/L） or CFS （ 14.91 ±2.61 ng/L） were significant lower than those in the control group （23.93 ± 2.01 ng/L） （P 〈 0.01 ）. The SFS group showed lower serum melatonin levels （20.72±2.54 ng/L） compared with the control group, but there were no statistical differences between the two groups. Serum melatonin levels in the epilepsy group were significantly lower than those in the CFS （ P 〈 0.05 ） and the SFS groups （ P 〈 0.01 ）. Conclusions Serum melatonin levels decreased in children with epilepsy or CFS. Supplement of exogenous melatonin might be a promising treatment for epilepsy and febrile seizures in children.