摘要
AIM： To investigate the effect of two-channel gastric electrical stimulation （GES） with trains of pulses on gastric emptying and slow waves.METHODS： Seven dogs implanted with four pairs of electrodes and equipped with a duodenal cannula were involved in this study. Two experiments were performed.The first experiment included a series of sessions in the fasting state with trains of short or long pulses, each lasted 10 min. A 5-min recording without pacing was made between two sessions. The second experiment was performed in three sessions （control, single-channel GES, and two-channel GES）. The stimulus was applied via the 1st pair of electrodes for single-channel GES （GES via one pair of electrodes located at 14 cm above the pylorus）, and simultaneously via the 1st and 3rd channels for two-channel GES （GES via two pairs of electrodes located at 6 and 14 cm above the pylorus）, Gastric liquid emptying was collected every 15 min via the cannula for 90 min.RESULTS： GES with trains of pulses at a pulse width of 4 ms or higher was able to entrain gastric slow waves. Two-channel GES was about 50% more efficient than single-channel GES in entraining gastric slow waves. Two-channel but not single-channel GES with trains of pulses was capable of accelerating gastric emptying in healthy dogs. Compared with the control session, two-channel GES significantly increased gastric emptying of liquids at 15 rain （79.0% ± 6.4% vs 61.3% ± 6.1%, P 〈 0.01）, 30 min （83.2% ± 6.3 % vs 68.2% ± 6.9%, P 〈 0.01）, 60 min （86.9% ± 5.5 % vs 74.1% ± 5.9%, P 〈 0.01）, and 90 rain （91.0% ± 3.4% vs 76.5% ± 5.9%, P 〈 0.01）.CONCLUSION： Two-channel GES with trains of pulses accelerates gastric emptying in healthy dogs and may have a therapeutic potential for the treatment of gastric motility disorders.
AIM:To investigate the effect of two-channel gastric electrical stimulation(GES) with trains of pulses on gastric emptying and slow waves.METHODS:Seven dogs implanted with four pairs of electrodes and equipped with a duodenal cannula were involved in this study.Two experiments were performed.The f irst experiment included a series of sessions in the fasting state with trains of short or long pulses,each lasted 10 min.A 5-min recording without pacing was made between two sessions.The second experiment was performed in three sessions(control,single-channel GES,and two-channel GES) .The stimulus was applied via the 1st pair of electrodes for single-channel GES(GES via one pair of electrodes located at 14 cm above the pylorus) ,and simultaneously via the 1st and 3rd channels for two-channel GES(GES via two pairs of electrodes located at 6 and 14 cm above the pylorus) .Gastric liquid emptying was collected every 15 min via the cannula for 90 min.RESULTS:GES with trains of pulses at a pulse width of 4 ms or higher was able to entrain gastric slow waves.Two-channel GES was about 50% more efficient than single-channel GES in entraining gastric slow waves.Two-channel but not single-channel GES with trains of pulses was capable of accelerating gastric emptying in healthy dogs.Compared with the control session,two-channel GES signif icantly increased gastric emptying of liquids at 15 min(79.0% ± 6.4% vs 61.3% ± 6.1%,P < 0.01) ,30 min(83.2% ± 6.3 % vs 68.2% ± 6.9%,P < 0.01) ,60 min(86.9% ± 5.5 % vs 74.1% ± 5.9%,P < 0.01) ,and 90 min(91.0% ± 3.4% vs 76.5% ± 5.9%,P < 0.01) .CONCLUSION:Two-channel GES with trains of pulses accelerates gastric emptying in healthy dogs and may have a therapeutic potential for the treatment of gastric motility disorders.
基金
Supported by Funds from Union Hospital and University of Texas Medical Branch
